A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas

Zhen Hua Lin, Eun Mee Han, Eung Seok Lee, Chul Hwan Kim, Han Kyeom Kim, Insun Kim, Young Sik Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

KIT is expressed not only in tumors derived from hematopoietic stem cells, melanocytes, germ cells, mast cells, and interstitial cells of Cajal, but also in other malignancies such as chromophobe renal cell carcinoma. This pattern of KIT expression prompted us to investigate the expression and mutation of c-kit gene exons 9, 11, 13, 17, and intron 17 in the different subtypes of renal cell carcinomas (n = 66) and non-neoplastic kidneys (n = 12). We found that KIT showed strong immunoreactivity in the cytoplasm of papillary renal cell carcinomas (100%), but on the cell membranes of chromophobe renal cell carcinomas (100%). Interestingly, a specific point mutation of the c-kit intron 17 (T->A) was found only in papillary renal cell carcinomas (94%). Our study demonstrates that the expression pattern and one mutation of c-kit may distinguish papillary renal cell carcinomas.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalModern Pathology
Volume17
Issue number6
DOIs
Publication statusPublished - 2004 Jun 1

Fingerprint

Renal Cell Carcinoma
Point Mutation
Introns
Interstitial Cells of Cajal
Mutation
Melanocytes
Hematopoietic Stem Cells
Mast Cells
Germ Cells
Exons
Neoplasms
Cytoplasm
Cell Membrane
Kidney
Genes

Keywords

  • c-kit
  • KIT
  • Papillary renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas. / Lin, Zhen Hua; Han, Eun Mee; Lee, Eung Seok; Kim, Chul Hwan; Kim, Han Kyeom; Kim, Insun; Kim, Young Sik.

In: Modern Pathology, Vol. 17, No. 6, 01.06.2004, p. 611-616.

Research output: Contribution to journalArticle

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AU - Kim, Young Sik

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