A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee, Junyoung Seo, Soyoung Kwak, Eun Ji Park, Dong Hee Na, Soyoun Kim, You Mie Lee, In-San Kim, Jong Sup Bae

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

Original languageEnglish
Pages (from-to)6637-6643
Number of pages7
JournalAdvanced Materials
Volume27
Issue number42
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

Thrombin Receptors
Protein C
Peptides
Bearings (structural)
Nanoparticles
Proteins
Acids

Keywords

  • ferritin
  • nanoparticles
  • PC-gla
  • sepsis
  • TRAP

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment. / Lee, Wonhwa; Seo, Junyoung; Kwak, Soyoung; Park, Eun Ji; Na, Dong Hee; Kim, Soyoun; Lee, You Mie; Kim, In-San; Bae, Jong Sup.

In: Advanced Materials, Vol. 27, No. 42, 01.11.2015, p. 6637-6643.

Research output: Contribution to journalArticle

Lee, Wonhwa ; Seo, Junyoung ; Kwak, Soyoung ; Park, Eun Ji ; Na, Dong Hee ; Kim, Soyoun ; Lee, You Mie ; Kim, In-San ; Bae, Jong Sup. / A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment. In: Advanced Materials. 2015 ; Vol. 27, No. 42. pp. 6637-6643.
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