A Dramatic Acceleration of the Pauson-Khand Reaction by Trimethylamine N-Oxide

Nakcheol Jeong, Young Keun Chung, Bun Yeoul Lee, Sang Hee Lee, Sung Eun Yoo

Research output: Contribution to journalArticle

239 Citations (Scopus)


The Pauson-Khand reaction (cocyclization of alkynes with alkenes and carbon monoxide by octacarbonyldicobalt leading to cyclopentenones) was greatly accelerated by trimethylamine N-oxide in the presence of oxygen in dichloromethane at 0 °C to room temperature. This process worked quite effectively for both intermolecular and intramolecular reactions.

Original languageEnglish
Pages (from-to)204-206
Number of pages3
Issue number3
Publication statusPublished - 1991 Mar 1
Externally publishedYes


ASJC Scopus subject areas

  • Organic Chemistry

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