A dynamic tree-based registration could handle possible large deformations among MR brain images

Pei Zhang, Guorong Wu, Yaozong Gao, Pew Thian Yap, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Multi-atlas segmentation is a powerful approach to automated anatomy delineation via fusing label information from a set of spatially normalized atlases. For simplicity, many existing methods perform pairwise image registration, leading to inaccurate segmentation especially when shape variation is large. In this paper, we propose a dynamic tree-based strategy for effective large-deformation registration and multi-atlas segmentation. To deal with local minima caused by large shape variation, coarse estimates of deformations are first obtained via alignment of automatically localized landmark points. The dynamic tree capturing the structural relationships between images is then employed to further reduce misalignment errors. Evaluation based on two real human brain datasets, ADNI and LPBA40, shows that our method significantly improves registration and segmentation accuracy.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalComputerized Medical Imaging and Graphics
Publication statusPublished - 2016 Sept 1


  • Corresponding points
  • Dynamic tree
  • Large-deformation image registration
  • Multi-atlas segmentation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design


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