A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

Sang Sun Park, Joong Kwon Choi, Eul Kgun Yum, Deok-Chan Ha

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

2,3-Disubstituted pyrrolo[2,3-b]pyridines were synthesized by palladium-catalyzed heteroannulation of 2-amino-3-iodopyridine derivatives and internal alkynes with Pd(OAc)2, LiCl, and KOAc in DMF. The 2-trimethylsilyl-3-methylpyrrolo[2,3-b]pyridine was transformed to 2-substituted-3-methylpyrrolo[2,3-b]pyridines.

Original languageEnglish
Pages (from-to)627-630
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number7
DOIs
Publication statusPublished - 1998 Feb 12

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Pyridines
Alkynes
Palladium
Derivatives
palladium(II) acetate
pyridine
pyrrolo(2, 3-b)pyridine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes. / Park, Sang Sun; Choi, Joong Kwon; Yum, Eul Kgun; Ha, Deok-Chan.

In: Tetrahedron Letters, Vol. 39, No. 7, 12.02.1998, p. 627-630.

Research output: Contribution to journalArticle

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