A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells

Hye Ri Kim, Rajesh Kumar, Woori Kim, Jae Hong Lee, Myungkoo Suh, Amit Sharma, Chang Hoe Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.

Original languageEnglish
Pages (from-to)7134-7137
Number of pages4
JournalChemical Communications
Volume52
Issue number44
DOIs
Publication statusPublished - 2016

Fingerprint

Tunicamycin
HeLa Cells
Endoplasmic Reticulum
Fluorescence
Membranes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells. / Kim, Hye Ri; Kumar, Rajesh; Kim, Woori; Lee, Jae Hong; Suh, Myungkoo; Sharma, Amit; Kim, Chang Hoe; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 52, No. 44, 2016, p. 7134-7137.

Research output: Contribution to journalArticle

Kim, Hye Ri ; Kumar, Rajesh ; Kim, Woori ; Lee, Jae Hong ; Suh, Myungkoo ; Sharma, Amit ; Kim, Chang Hoe ; Kang, Chulhun ; Kim, Jong Seung. / A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells. In: Chemical Communications. 2016 ; Vol. 52, No. 44. pp. 7134-7137.
@article{3acd650da00a4849bcf3ab67fd0a4050,
title = "A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells",
abstract = "Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.",
author = "Kim, {Hye Ri} and Rajesh Kumar and Woori Kim and Lee, {Jae Hong} and Myungkoo Suh and Amit Sharma and Kim, {Chang Hoe} and Chulhun Kang and Kim, {Jong Seung}",
year = "2016",
doi = "10.1039/c6cc02330d",
language = "English",
volume = "52",
pages = "7134--7137",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "44",

}

TY - JOUR

T1 - A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells

AU - Kim, Hye Ri

AU - Kumar, Rajesh

AU - Kim, Woori

AU - Lee, Jae Hong

AU - Suh, Myungkoo

AU - Sharma, Amit

AU - Kim, Chang Hoe

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2016

Y1 - 2016

N2 - Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.

AB - Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.

UR - http://www.scopus.com/inward/record.url?scp=84971320751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971320751&partnerID=8YFLogxK

U2 - 10.1039/c6cc02330d

DO - 10.1039/c6cc02330d

M3 - Article

C2 - 27169842

AN - SCOPUS:84971320751

VL - 52

SP - 7134

EP - 7137

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 44

ER -