A fibrin gel carrier system for islet transplantation into kidney subcapsule

Jong Yeon Lim, Byoung Hoon Min, Byoung Geun Kim, Hyun Ju Han, Soo Jin Kim, Chan Wha Kim, Sung Sik Han, Jun Seop Shin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Islet transplantation is a promising therapeutic option for type 1 diabetes, and actively performed in the clinic as well as in the animal experiments. For the rodent experiments, islet transplantation into kidney subcapsule is widely used to assess islet quality, however, it is often difficult to do using a polyethylene tubing and fine needle because of inherent dead volume of needle and stickiness of the tubing to islets. This problem makes it difficult to interpret the physiological response to different islet doses. Here, we developed a simple fibrin gel carrier system for islet transplantation into kidney subcapsule and utilized it to determine the marginal islet mass sufficient for correction of hyperglycemia in diabetic nude mice.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalActa Diabetologica
Volume46
Issue number3
DOIs
Publication statusPublished - 2009 Sep 1

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Keywords

  • Diabetes
  • Fibrin gel
  • Islet transplantation
  • Marginal mass

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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