A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

Sankarprasad Bhuniya, Min Hee Lee, Hyun Mi Jeon, Ji Hye Han, Jae Hong Lee, Nayoung Park, Sukhendu Maiti, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 s able to monitor drug delivery and cellular imaging.

Original languageEnglish
Pages (from-to)7141-7143
Number of pages3
JournalChemical Communications
Volume49
Issue number64
DOIs
Publication statusPublished - 2013 Jul 16

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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