A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

Seo Hee Yim; Hyung Jin Cha; Se Jin Park; Yeajee Yim; Jae Sung Woo; Dal Hee Min

doi:10.1039/c9cc10054g

A fluorescent nanobiosensor for the facile analysis of m⁶A RNA demethylase activity

Seo Hee Yim, Hyung Jin Cha, Se Jin Park, Yeajee Yim, Jae Sung Woo, Dal Hee Min

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.

Original language	English
Pages (from-to)	4716-4719
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	34
DOIs	https://doi.org/10.1039/c9cc10054g
Publication status	Published - 2020 Apr 30

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c9cc10054g

Cite this

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title = "A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity",

abstract = "RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.",

author = "Yim, {Seo Hee} and Cha, {Hyung Jin} and Park, {Se Jin} and Yeajee Yim and Woo, {Jae Sung} and Min, {Dal Hee}",

note = "Funding Information: This work was supported by the Basic Science Research Program (2016R1E1A1A01941202), the International S&T Cooperation Program (2014K1B1A1073716), and the Research Centre Program (IBS-R008-D1) of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) and by Lemonex Inc. (LEMONEX-SN201709-3-12, LEMONEX-SN201901-3-30). Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",

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T1 - A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity

AU - Yim, Seo Hee

AU - Cha, Hyung Jin

AU - Park, Se Jin

AU - Yim, Yeajee

AU - Woo, Jae Sung

AU - Min, Dal Hee

N1 - Funding Information: This work was supported by the Basic Science Research Program (2016R1E1A1A01941202), the International S&T Cooperation Program (2014K1B1A1073716), and the Research Centre Program (IBS-R008-D1) of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) and by Lemonex Inc. (LEMONEX-SN201709-3-12, LEMONEX-SN201901-3-30). Publisher Copyright: This journal is © The Royal Society of Chemistry.

PY - 2020/4/30

Y1 - 2020/4/30

N2 - RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.

AB - RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.

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