A forensic autopsy case of death in a patient with pseudoxanthoma elasticum - Dermatopathologic findings as a clue of the cause of death

Seong Hwan Park, Gi Yeong Huh, Huguo Piao, Se Hoon Kim, Juck Joon Hwang

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder, characterized by papular skin lesions and cutaneous laxity caused by fragmentation and mineralization of elastic fibers. Although vascular and retinal aspects of this disease and their associated complications are well characterized, few authors have focused on the increased incidence of epilepsy in patients with PXE. A 28-year-old Korean male was found dead in his work place with bloody-foamy discharge from his mouth and nostrils. He reportedly had a convulsive episode 5 days prior to his death in the work place. The skin showed generalized laxity and many creases with maculopapular pigmentations. A histopathologic examination of the skin revealed Pseudoxanthoma elasticum. Based on the histopathological findings and medical history, death was postulated to be due to 'an internal cause, possibly related to a seizure attack'. Our findings suggest that histopathologic examinations of any lesions found during the forensic autopsy should be encouraged.

    Original languageEnglish
    Pages (from-to)543-545
    Number of pages3
    JournalJournal of Forensic and Legal Medicine
    Volume20
    Issue number5
    DOIs
    Publication statusPublished - 2013 Jul

    Keywords

    • Forensic science Forensic pathology Epilepsy Pseudoxanthoma elasticum Autopsy Dermatopathology

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Law

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