A four-layer DOI detector with a relative offset for use in an animal PET system

Mikiko Ito, Jae Sung Lee, Sun Il Kwon, Geon Song Lee, Byungsik Hong, Kyong Sei Lee, Kwang Souk Sim, Seok Jae Lee, June Tak Rhee, Seong Jong Hong

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

For animal PET systems to achieve high sensitivity without adversely affecting spatial resolution, they must have the ability to measure depth-of-interaction (DOI). In this paper, we propose a novel four-layer PET system, and present the performances of modules built to verify the concept of the system. Each layer in the four-layer PET system has a relative offset of half a crystal pitch from other layers. Performances of the four-layer detector were estimated using a GATE Monte Carlo simulation code. The proposed system consists of six H9500 PMTs, each of which contains 3193 crystals. A sensitivity of 11.8% was obtained at the FOV center position of the proposed system. To verify the concept, we tested a PET module constructed using a H9500 flat panel PMT and LYSO crystals of cross-sectional area 1.5 × 1.5 mm2. The PET module was irradiated with a 1.8 MBq 22Na radiation source from the front or side of the crystals to obtain flood images of each crystal. Collimation for side irradiation was achieved using a pair of lead blocks of dimension 50 × 100 × 200 mm3. All crystals in the four layers were clearly identified in flood images, thus verifying the DOI capability of the proposed four-layer PET system. We also investigated the optimal combination of crystal lengths in the four-layer PET system using the GATE Monte Carlo simulation code to generate events from simulated radiation sources, and using the ML-EM algorithm to reconstruct simulated radiation sources. The combination of short crystal lengths near radiation sources and long crystal lengths near the PMT provides better spatial resolution than combinations of same crystal lengths in the four-layer PET system.

Original languageEnglish
Article number5485133
Pages (from-to)976-981
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume57
Issue number3 PART 1
DOIs
Publication statusPublished - 2010 Jun 1

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animals
Animals
Detectors
Crystals
detectors
crystals
radiation sources
interactions
GARP Atlantic Tropical Experiment
Radiation
modules
spatial resolution
sensitivity
collimation
simulation
Irradiation
irradiation

Keywords

  • Depth of interaction (DOI))
  • Four-layer animal PET
  • GATE monte carlo simulation
  • H9500 photomultiplier tube (PMT)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics

Cite this

Ito, M., Lee, J. S., Kwon, S. I., Lee, G. S., Hong, B., Lee, K. S., ... Hong, S. J. (2010). A four-layer DOI detector with a relative offset for use in an animal PET system. IEEE Transactions on Nuclear Science, 57(3 PART 1), 976-981. [5485133]. https://doi.org/10.1109/TNS.2010.2044892

A four-layer DOI detector with a relative offset for use in an animal PET system. / Ito, Mikiko; Lee, Jae Sung; Kwon, Sun Il; Lee, Geon Song; Hong, Byungsik; Lee, Kyong Sei; Sim, Kwang Souk; Lee, Seok Jae; Rhee, June Tak; Hong, Seong Jong.

In: IEEE Transactions on Nuclear Science, Vol. 57, No. 3 PART 1, 5485133, 01.06.2010, p. 976-981.

Research output: Contribution to journalArticle

Ito, M, Lee, JS, Kwon, SI, Lee, GS, Hong, B, Lee, KS, Sim, KS, Lee, SJ, Rhee, JT & Hong, SJ 2010, 'A four-layer DOI detector with a relative offset for use in an animal PET system', IEEE Transactions on Nuclear Science, vol. 57, no. 3 PART 1, 5485133, pp. 976-981. https://doi.org/10.1109/TNS.2010.2044892
Ito, Mikiko ; Lee, Jae Sung ; Kwon, Sun Il ; Lee, Geon Song ; Hong, Byungsik ; Lee, Kyong Sei ; Sim, Kwang Souk ; Lee, Seok Jae ; Rhee, June Tak ; Hong, Seong Jong. / A four-layer DOI detector with a relative offset for use in an animal PET system. In: IEEE Transactions on Nuclear Science. 2010 ; Vol. 57, No. 3 PART 1. pp. 976-981.
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