A generalized framework for quantifying the dynamics of EEG event-related desynchronization

Steven Lemm, Klaus Muller, Gabriel Curio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Brains were built by evolution to react swiftly to environmental challenges. Thus, sensory stimuli must be processed ad hoc, i.e., independent - to a large extent - from the momentary brain state incidentally prevailing during stimulus occurrence. Accordingly, computational neuroscience strives to model the robust processing of stimuli in the presence of dynamical cortical states. A pivotal feature of ongoing brain activity is the regional predominance of EEG eigenrhythms, such as the occipital alpha or the pericentral mu rhythm, both peaking spectrally at 10 Hz. Here, we establish a novel generalized concept to measure event-related desynchronization (ERD), which allows one to model neural oscillatory dynamics also in the presence of dynamical cortical states. Specifically, we demonstrate that a somatosensory stimulus causes a stereotypic sequence of first an ERD and then an ensuing amplitude overshoot (event-related synchronization), which at a dynamical cortical state becomes evident only if the natural relaxation dynamics of unperturbed EEG rhythms is utilized as reference dynamics. Moreover, this computational approach also encompasses the more general notion of a "conditional ERD," through which candidate explanatory variables can be scrutinized with regard to their possible impact on a particular oscillatory dynamics under study. Thus, the generalized ERD represents a powerful novel analysis tool for extending our understanding of inter-trial variability of evoked responses and therefore the robust processing of environmental stimuli.

Original languageEnglish
Article numbere1000453
JournalPLoS Computational Biology
Volume5
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Fingerprint

Desynchronization
Electroencephalography
brain
Brain
Neurosciences
neurophysiology
Computational Neuroscience
Processing
Overshoot
Synchronization
Framework
Electroencephalogram
Model
Demonstrate

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Computational Theory and Mathematics
  • Ecology
  • Modelling and Simulation
  • Cellular and Molecular Neuroscience

Cite this

A generalized framework for quantifying the dynamics of EEG event-related desynchronization. / Lemm, Steven; Muller, Klaus; Curio, Gabriel.

In: PLoS Computational Biology, Vol. 5, No. 8, e1000453, 01.08.2009.

Research output: Contribution to journalArticle

Lemm, Steven ; Muller, Klaus ; Curio, Gabriel. / A generalized framework for quantifying the dynamics of EEG event-related desynchronization. In: PLoS Computational Biology. 2009 ; Vol. 5, No. 8.
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