A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder

Heon-Jeong Lee, Hyun Goo Woo, Tiffany A. Greenwood, Daniel F. Kripke, John R. Kelsoe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
JournalJournal of Affective Disorders
Volume145
Issue number2
DOIs
Publication statusPublished - 2013 Feb 20

Fingerprint

Genome-Wide Association Study
Bipolar Disorder
Introns
Haplotypes
Genes
Single Nucleotide Polymorphism
Genotype
Genome

Keywords

  • Bipolar disorder
  • Genome-wide association
  • Seasonal pattern

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. / Lee, Heon-Jeong; Woo, Hyun Goo; Greenwood, Tiffany A.; Kripke, Daniel F.; Kelsoe, John R.

In: Journal of Affective Disorders, Vol. 145, No. 2, 20.02.2013, p. 200-207.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Woo, Hyun Goo ; Greenwood, Tiffany A. ; Kripke, Daniel F. ; Kelsoe, John R. / A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. In: Journal of Affective Disorders. 2013 ; Vol. 145, No. 2. pp. 200-207.
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