Abstract
Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 200-207 |
| Number of pages | 8 |
| Journal | Journal of Affective Disorders |
| Volume | 145 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Feb 20 |
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Keywords
- Bipolar disorder
- Genome-wide association
- Seasonal pattern
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. / Lee, Heon-Jeong; Woo, Hyun Goo; Greenwood, Tiffany A.; Kripke, Daniel F.; Kelsoe, John R.
In: Journal of Affective Disorders, Vol. 145, No. 2, 20.02.2013, p. 200-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder
AU - Lee, Heon-Jeong
AU - Woo, Hyun Goo
AU - Greenwood, Tiffany A.
AU - Kripke, Daniel F.
AU - Kelsoe, John R.
PY - 2013/2/20
Y1 - 2013/2/20
N2 - Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.
AB - Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10-7, OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12×10-7, OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.
KW - Bipolar disorder
KW - Genome-wide association
KW - Seasonal pattern
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U2 - 10.1016/j.jad.2012.07.032
DO - 10.1016/j.jad.2012.07.032
M3 - Article
VL - 145
SP - 200
EP - 207
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 2
ER -