A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men

Sangmee Ahn Jo, Eun Kyung Kim, Moon Ho Park, Changsu Han, Hyun Young Park, Yangsoo Jang, Byung Joon Song, Inho Jo

Research output: Contribution to journalArticle

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Abstract

Background: A homozygous mutant (ALDH2*2/*2) of the gene for mitochondrial aldehyde dehydrogenase 2 (ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population. Method: The subjects consisted of 122 men (60-81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60-84 y) without MI were selected as controls from the Ansan Geriatric Study. ALDH2 genotypes were determined using the TaqMan fluorogenic 5′ nuclease polymerase chain reaction assay. Results: Genotypes carrying the mutant ALDH2 allele (ALDH2*1/*2 plus ALDH2*2/*2) were significantly more frequent in patients with MI than in the controls (42.6% vs. 30.5%, P = 0.0163). Multiple logistic regression analysis revealed that ALDH2*1/*2 plus ALDH2*2/*2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio = 1.976, 95% CI: 1.202-3.248). Conclusions: ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalClinica Chimica Acta
Volume382
Issue number1-2
DOIs
Publication statusPublished - 2007 Jul 1

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Aldehyde Dehydrogenase
Polymorphism
Genes
Myocardial Infarction
Genotype
Korea
Geriatrics
Codon
HDL Cholesterol
Mitochondrial Aldehyde Dehydrogenase
Body Mass Index
Logistic Models
Polymerase chain reaction
Alleles
Odds Ratio
Regression Analysis
Regression analysis
Polymerase Chain Reaction
Logistics
Assays

Keywords

  • Aldehyde dehydrogenase 2
  • Koreans
  • Myocardial infarction
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. / Jo, Sangmee Ahn; Kim, Eun Kyung; Park, Moon Ho; Han, Changsu; Park, Hyun Young; Jang, Yangsoo; Song, Byung Joon; Jo, Inho.

In: Clinica Chimica Acta, Vol. 382, No. 1-2, 01.07.2007, p. 43-47.

Research output: Contribution to journalArticle

Jo, Sangmee Ahn ; Kim, Eun Kyung ; Park, Moon Ho ; Han, Changsu ; Park, Hyun Young ; Jang, Yangsoo ; Song, Byung Joon ; Jo, Inho. / A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. In: Clinica Chimica Acta. 2007 ; Vol. 382, No. 1-2. pp. 43-47.
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