A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection

Yun Choi, Young Chan Kwon, Soo In Kim, Jung Min Park, Kyung Hee Lee, Byung Yoon Ahn

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Hantaan virus (HTNV) is a pathogenic hantavirus that causes hemorrhagic fever with renal syndrome (HFRS). HTNV infection is mediated by αvβ3 integrin. We used protein blots of Vero E6 cell homogenates to demonstrate that radiolabeled HTNV virions bind to gC1qR/p32, the acidic 32-kDa protein known as the receptor for the globular head domain of complement C1q. RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells. Conversely, transient expression of either simian or human gC1qR/p32 rendered non-permissive CHO cells susceptible to HTNV infection. These results suggest an important role for gC1qR/p32 in HTNV infection and pathogenesis.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalVirology
Volume381
Issue number2
DOIs
Publication statusPublished - 2008 Nov 25

Keywords

  • Hantavirus
  • Infection
  • Viral binding
  • gC1qR/p32

ASJC Scopus subject areas

  • Virology

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