A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra

Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Jason P. Burgess, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, Nicholas H. Oberlies

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

(Chemical Equation Presented) Three new ent-trachylobane diterpenoids (1-3) were isolated and structures elucidated from Mitrephora glabra Scheff. (Annonaceae). Mitrephorone A (1) possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachylobanes. All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent.

Original languageEnglish
Pages (from-to)5709-5712
Number of pages4
JournalOrganic Letters
Volume7
Issue number25
DOIs
Publication statusPublished - 2005 Dec 8

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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