A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fatto modulate serum hdl-cholesterol concentrations

Inkyung Baik, Seung Ku Lee, Seong Hwan Kim, Chol Shin

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11 Citations (Scopus)


There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genomewide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D'= 0.99) of LPL. We found that carrying the T allele reflecting the LPL 3447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction < 0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL×447 allele benefit frommoderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL × 447 allele need to control body weight to prevent hypertriglyceridemia.

Original languageEnglish
Pages (from-to)1618-1625
Number of pages8
JournalJournal of Nutrition
Issue number10
Publication statusPublished - 2013 Oct 22


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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