A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fatto modulate serum hdl-cholesterol concentrations

Inkyung Baik, Seung Ku Lee, Seong Hwan Kim, Chol Shin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genomewide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D'= 0.99) of LPL. We found that carrying the T allele reflecting the LPL 3447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction < 0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL×447 allele benefit frommoderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL × 447 allele need to control body weight to prevent hypertriglyceridemia.

Original languageEnglish
Pages (from-to)1618-1625
Number of pages8
JournalJournal of Nutrition
Volume143
Issue number10
DOIs
Publication statusPublished - 2013 Oct 22

Fingerprint

Lipoprotein Lipase
Alcohol Drinking
HDL Cholesterol
Cholesterol
Serum
Genes
Triglycerides
Alleles
Unsaturated Fats
Life Style
Linear Models
Prospective Studies
Hypertriglyceridemia
Linkage Disequilibrium
Serine
Coronary Disease
Body Mass Index
Cohort Studies
Obesity
Biomarkers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fatto modulate serum hdl-cholesterol concentrations. / Baik, Inkyung; Lee, Seung Ku; Kim, Seong Hwan; Shin, Chol.

In: Journal of Nutrition, Vol. 143, No. 10, 22.10.2013, p. 1618-1625.

Research output: Contribution to journalArticle

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