A Low Geriatric Nutritional Risk Index is Associated with Aggressive Pathologic Characteristics and Poor Survival after Nephrectomy in Clear Renal Cell Carcinoma: A Multicenter Retrospective Study

Ho Won Kang, Sung Pil Seo, Won Tae Kim, Seok Joong Yun, Sang Cheol Lee, Wun Jae Kim, Eu Chang Hwang, Seok Ho Kang, Sung Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Seok Soo Byun, Yong June Kim

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Abstract

Purpose: To investigated the prognostic significance of the geriatric nutritional risk index (GNRI) in patients with surgically treated clear cell renal cell carcinoma (ccRCC). Patients and methods: We retrospectively selected 4,591 consecutive patients with surgically treated ccRCC from a multi-institutional Korean collaboration between 1988 and 2015. The clinical significance of the GNRI as a continuous and categorical variable was determined. Results: Preoperative low GNRI was significantly associated with older age, low body mass index, presence of diabetes, poor performance status, and presence of symptoms at diagnosis, as well as pathologic features such as aggressive tumor characteristics including large tumor size, advanced stage, high nuclear grade, lymphovascular invasion, sarcomatous differentiation, and tumor necrosis. A low GNRI was significantly associated with a short recurrence-free survival (RFS) in localized (pT1-2N0M0) ccRCC and cancer-specific survival (CSS) in the entire cohort, and with short RFS and CSS in the subgroup analysis according to age categories (≤65 and >65 years). Multivariate Cox regression analysis showed that preoperative GNRI, as a continuous or categorical variable, was an independent predictor of RFS and CSS. Conclusion: Malnutrition as assessed by the preoperative GNRI is associated with aggressive tumor characteristics and poor survival in patients with surgically treated ccRCC.

Original languageEnglish
JournalNutrition and Cancer
DOIs
Publication statusPublished - 2019 Jan 1

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Nutrition Assessment
Nephrectomy
Renal Cell Carcinoma
Geriatrics
Multicenter Studies
Retrospective Studies
Survival
Neoplasms
Recurrence
Malnutrition
Body Mass Index
Necrosis
Regression Analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

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A Low Geriatric Nutritional Risk Index is Associated with Aggressive Pathologic Characteristics and Poor Survival after Nephrectomy in Clear Renal Cell Carcinoma : A Multicenter Retrospective Study. / Kang, Ho Won; Seo, Sung Pil; Kim, Won Tae; Yun, Seok Joong; Lee, Sang Cheol; Kim, Wun Jae; Hwang, Eu Chang; Kang, Seok Ho; Hong, Sung Hoo; Chung, Jinsoo; Kwon, Tae Gyun; Kim, Hyeon Hoe; Kwak, Cheol; Byun, Seok Soo; Kim, Yong June.

In: Nutrition and Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Kang, Ho Won ; Seo, Sung Pil ; Kim, Won Tae ; Yun, Seok Joong ; Lee, Sang Cheol ; Kim, Wun Jae ; Hwang, Eu Chang ; Kang, Seok Ho ; Hong, Sung Hoo ; Chung, Jinsoo ; Kwon, Tae Gyun ; Kim, Hyeon Hoe ; Kwak, Cheol ; Byun, Seok Soo ; Kim, Yong June. / A Low Geriatric Nutritional Risk Index is Associated with Aggressive Pathologic Characteristics and Poor Survival after Nephrectomy in Clear Renal Cell Carcinoma : A Multicenter Retrospective Study. In: Nutrition and Cancer. 2019.
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abstract = "Purpose: To investigated the prognostic significance of the geriatric nutritional risk index (GNRI) in patients with surgically treated clear cell renal cell carcinoma (ccRCC). Patients and methods: We retrospectively selected 4,591 consecutive patients with surgically treated ccRCC from a multi-institutional Korean collaboration between 1988 and 2015. The clinical significance of the GNRI as a continuous and categorical variable was determined. Results: Preoperative low GNRI was significantly associated with older age, low body mass index, presence of diabetes, poor performance status, and presence of symptoms at diagnosis, as well as pathologic features such as aggressive tumor characteristics including large tumor size, advanced stage, high nuclear grade, lymphovascular invasion, sarcomatous differentiation, and tumor necrosis. A low GNRI was significantly associated with a short recurrence-free survival (RFS) in localized (pT1-2N0M0) ccRCC and cancer-specific survival (CSS) in the entire cohort, and with short RFS and CSS in the subgroup analysis according to age categories (≤65 and >65 years). Multivariate Cox regression analysis showed that preoperative GNRI, as a continuous or categorical variable, was an independent predictor of RFS and CSS. Conclusion: Malnutrition as assessed by the preoperative GNRI is associated with aggressive tumor characteristics and poor survival in patients with surgically treated ccRCC.",
author = "Kang, {Ho Won} and Seo, {Sung Pil} and Kim, {Won Tae} and Yun, {Seok Joong} and Lee, {Sang Cheol} and Kim, {Wun Jae} and Hwang, {Eu Chang} and Kang, {Seok Ho} and Hong, {Sung Hoo} and Jinsoo Chung and Kwon, {Tae Gyun} and Kim, {Hyeon Hoe} and Cheol Kwak and Byun, {Seok Soo} and Kim, {Yong June}",
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T1 - A Low Geriatric Nutritional Risk Index is Associated with Aggressive Pathologic Characteristics and Poor Survival after Nephrectomy in Clear Renal Cell Carcinoma

T2 - A Multicenter Retrospective Study

AU - Kang, Ho Won

AU - Seo, Sung Pil

AU - Kim, Won Tae

AU - Yun, Seok Joong

AU - Lee, Sang Cheol

AU - Kim, Wun Jae

AU - Hwang, Eu Chang

AU - Kang, Seok Ho

AU - Hong, Sung Hoo

AU - Chung, Jinsoo

AU - Kwon, Tae Gyun

AU - Kim, Hyeon Hoe

AU - Kwak, Cheol

AU - Byun, Seok Soo

AU - Kim, Yong June

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To investigated the prognostic significance of the geriatric nutritional risk index (GNRI) in patients with surgically treated clear cell renal cell carcinoma (ccRCC). Patients and methods: We retrospectively selected 4,591 consecutive patients with surgically treated ccRCC from a multi-institutional Korean collaboration between 1988 and 2015. The clinical significance of the GNRI as a continuous and categorical variable was determined. Results: Preoperative low GNRI was significantly associated with older age, low body mass index, presence of diabetes, poor performance status, and presence of symptoms at diagnosis, as well as pathologic features such as aggressive tumor characteristics including large tumor size, advanced stage, high nuclear grade, lymphovascular invasion, sarcomatous differentiation, and tumor necrosis. A low GNRI was significantly associated with a short recurrence-free survival (RFS) in localized (pT1-2N0M0) ccRCC and cancer-specific survival (CSS) in the entire cohort, and with short RFS and CSS in the subgroup analysis according to age categories (≤65 and >65 years). Multivariate Cox regression analysis showed that preoperative GNRI, as a continuous or categorical variable, was an independent predictor of RFS and CSS. Conclusion: Malnutrition as assessed by the preoperative GNRI is associated with aggressive tumor characteristics and poor survival in patients with surgically treated ccRCC.

AB - Purpose: To investigated the prognostic significance of the geriatric nutritional risk index (GNRI) in patients with surgically treated clear cell renal cell carcinoma (ccRCC). Patients and methods: We retrospectively selected 4,591 consecutive patients with surgically treated ccRCC from a multi-institutional Korean collaboration between 1988 and 2015. The clinical significance of the GNRI as a continuous and categorical variable was determined. Results: Preoperative low GNRI was significantly associated with older age, low body mass index, presence of diabetes, poor performance status, and presence of symptoms at diagnosis, as well as pathologic features such as aggressive tumor characteristics including large tumor size, advanced stage, high nuclear grade, lymphovascular invasion, sarcomatous differentiation, and tumor necrosis. A low GNRI was significantly associated with a short recurrence-free survival (RFS) in localized (pT1-2N0M0) ccRCC and cancer-specific survival (CSS) in the entire cohort, and with short RFS and CSS in the subgroup analysis according to age categories (≤65 and >65 years). Multivariate Cox regression analysis showed that preoperative GNRI, as a continuous or categorical variable, was an independent predictor of RFS and CSS. Conclusion: Malnutrition as assessed by the preoperative GNRI is associated with aggressive tumor characteristics and poor survival in patients with surgically treated ccRCC.

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