A mechanism for the effect of endocrine disrupting chemicals on placentation

Changwon Yang, Gwonhwa Song, Whasun Lim

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Numerous recent studies have shown that endocrine disrupting chemicals (EDCs) in the body of pregnant women can pass through the placenta and be exposed to the fetus, leading to fetal development and cognitive impairment. Placentation through invasion of trophoblast cells and vascular remodeling is essential to maintaining maternal and fetal health throughout the pregnancy. Abnormal placentation can lead to pregnancy disorders such as preeclampsia (PE) and intrauterine growth retardation (IUGR). However, many studies have not been conducted on whether EDCs can inhibit the development and function of the placenta. Isolating placental tissues to analyze the effect of EDCs on placentation has several limitations. In this review, we discussed the types of EDCs that can pass through the placental barrier and accumulate in the placenta with relative outcome. EDCs can be released from a variety of products including plasticizers, pesticides, and retardant. We also discussed the development and dysfunction of the placenta when EDCs were treated on trophoblast cells or pregnant rodent models. The effects of EDCs on the placenta of livestock are also discussed, together with the molecular mechanism of EDCs acting in trophoblast cells. We describe how EDCs cross the membrane of trophoblasts to regulate signaling pathways, causing genetic and epigenetic changes that lead to changes in cell viability and invasiveness. Further studies on the effects of EDCs on placenta may draw attention to the correct use of products containing EDCs during pregnancy.

Original languageEnglish
Pages (from-to)326-336
Number of pages11
JournalChemosphere
Volume231
DOIs
Publication statusPublished - 2019 Sep 1

Fingerprint

Endocrine Disruptors
Placentation
Placenta
Trophoblasts
pregnancy
Pregnancy
effect
chemical
Plasticizers
invasiveness
Fetal Growth Retardation
Livestock
Fetal Development
Pesticides
Pre-Eclampsia
Epigenomics
Agriculture
rodent
Pregnant Women
livestock

Keywords

  • BPA
  • EDCs
  • Phthalate
  • Placenta
  • Trophoblast

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

A mechanism for the effect of endocrine disrupting chemicals on placentation. / Yang, Changwon; Song, Gwonhwa; Lim, Whasun.

In: Chemosphere, Vol. 231, 01.09.2019, p. 326-336.

Research output: Contribution to journalReview article

Yang, Changwon ; Song, Gwonhwa ; Lim, Whasun. / A mechanism for the effect of endocrine disrupting chemicals on placentation. In: Chemosphere. 2019 ; Vol. 231. pp. 326-336.
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