A mechanistic model for drug release from PLGA-based drug eluting stent

A computational study

Jahed Naghipoor, Timon Rabczuk

Research output: Contribution to journalArticle

Abstract

Atherosclerosis in the coronary artery is one of the leading causes of death in the world. The stenting as a minimally invasive technique was considered as an effective tool to reduce the severity of atherosclerotic stenosis. In-stent restenosis is the main drawback of the stenting in the coronary artery. Understanding the mechanism of drug release from drug-eluting stents and drug uptake in the arterial wall and obtaining more information about their functionality using mathematical modeling and numerical simulation, could be considered as a predictive tool to investigate in-stent restenosis growth which is experimentally expensive to study. In this work, the local delivery of a therapeutic agent from a PLGA-based bioabsorbable stent implanted in a coronary artery to predict the drug release as well as spatio-temporal drug distribution in a coronary artery with a vulnerable plaque is mathematically modeled and numerically simulated. The effect of copolymer ratio on drug release has been also investigated.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalComputers in Biology and Medicine
Volume90
DOIs
Publication statusPublished - 2017 Nov 1
Externally publishedYes

Fingerprint

Drug-Eluting Stents
Stents
Coronary Vessels
Pharmaceutical Preparations
Cause of Death
Atherosclerosis
Pathologic Constriction
Copolymers
Drug Liberation
polylactic acid-polyglycolic acid copolymer
Computer simulation
Growth
Therapeutics

Keywords

  • Numerical simulation
  • PLGA-based bioabsorbable stent
  • Viscoelasticity

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

Cite this

A mechanistic model for drug release from PLGA-based drug eluting stent : A computational study. / Naghipoor, Jahed; Rabczuk, Timon.

In: Computers in Biology and Medicine, Vol. 90, 01.11.2017, p. 15-22.

Research output: Contribution to journalArticle

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