A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis

Min Gu Lee, Young Ho Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To explore whether the mucin (MUC) 5B rs35705950 T/G polymorphism confers susceptibility to idiopathic pulmonary fibrosis (IPF).Methods: A meta-analysis was conducted to determine associations between the MUC5B rs35705950 T/G polymorphism and either IPF or connective tissue disease-associated interstitial lung disease (CTD-ILD). We used the allele contrast, recessive, dominant, and additive models. A total of 12 IPF studies comprising 2859 patients and 6901 controls and four CTD-ILD studies involving 903 patients and 3306 controls were included in the meta-analysis.Results: There was a significant association between the Tallele of the MUC5B rs35705950 polymorphism and IPF in all subjects (OR 3.768, 95 % CI 2.935–4.836, p < 1.0 × 10−8). Analysis after stratification by ethnicity indicated that the Tallele was significantly associated with IPF in Europeans and Asians (OR 3.728, 95 % CI 2.858–4.863, p < 1.0 × 10−8; OR 4.334, 95 % CI 2.186–8.594, p = 2.6 × 10−6). However, there was no association between the Tallele and CTD-ILD in all subjects (OR 1.130, 95 % CI 0.937–1.363, p = 0.200), and in Europeans and Asians. Subgroup analysis by CTD type revealed no association between the Tallele and systemic sclerosis-associated ILD (SSc-ILD) and other CTD-ILDs.Conclusions: The MUC5B rs35705950 T/G polymorphism confers susceptibility to IPF in Europeans and Asians, but is not associated with susceptibility to CTD-ILD.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalInflammation Research
Volume64
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Idiopathic Pulmonary Fibrosis
Meta-Analysis
Connective Tissue Diseases
Interstitial Lung Diseases
Mucin-5B
Systemic Scleroderma
Alleles

Keywords

  • IPF
  • Meta-analysis
  • MUC5B
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

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title = "A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis",
abstract = "Objective: To explore whether the mucin (MUC) 5B rs35705950 T/G polymorphism confers susceptibility to idiopathic pulmonary fibrosis (IPF).Methods: A meta-analysis was conducted to determine associations between the MUC5B rs35705950 T/G polymorphism and either IPF or connective tissue disease-associated interstitial lung disease (CTD-ILD). We used the allele contrast, recessive, dominant, and additive models. A total of 12 IPF studies comprising 2859 patients and 6901 controls and four CTD-ILD studies involving 903 patients and 3306 controls were included in the meta-analysis.Results: There was a significant association between the Tallele of the MUC5B rs35705950 polymorphism and IPF in all subjects (OR 3.768, 95 {\%} CI 2.935–4.836, p < 1.0 × 10−8). Analysis after stratification by ethnicity indicated that the Tallele was significantly associated with IPF in Europeans and Asians (OR 3.728, 95 {\%} CI 2.858–4.863, p < 1.0 × 10−8; OR 4.334, 95 {\%} CI 2.186–8.594, p = 2.6 × 10−6). However, there was no association between the Tallele and CTD-ILD in all subjects (OR 1.130, 95 {\%} CI 0.937–1.363, p = 0.200), and in Europeans and Asians. Subgroup analysis by CTD type revealed no association between the Tallele and systemic sclerosis-associated ILD (SSc-ILD) and other CTD-ILDs.Conclusions: The MUC5B rs35705950 T/G polymorphism confers susceptibility to IPF in Europeans and Asians, but is not associated with susceptibility to CTD-ILD.",
keywords = "IPF, Meta-analysis, MUC5B, Polymorphism",
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T1 - A meta-analysis examining the association between the MUC5B rs35705950 T/G polymorphism and susceptibility to idiopathic pulmonary fibrosis

AU - Lee, Min Gu

AU - Lee, Young Ho

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N2 - Objective: To explore whether the mucin (MUC) 5B rs35705950 T/G polymorphism confers susceptibility to idiopathic pulmonary fibrosis (IPF).Methods: A meta-analysis was conducted to determine associations between the MUC5B rs35705950 T/G polymorphism and either IPF or connective tissue disease-associated interstitial lung disease (CTD-ILD). We used the allele contrast, recessive, dominant, and additive models. A total of 12 IPF studies comprising 2859 patients and 6901 controls and four CTD-ILD studies involving 903 patients and 3306 controls were included in the meta-analysis.Results: There was a significant association between the Tallele of the MUC5B rs35705950 polymorphism and IPF in all subjects (OR 3.768, 95 % CI 2.935–4.836, p < 1.0 × 10−8). Analysis after stratification by ethnicity indicated that the Tallele was significantly associated with IPF in Europeans and Asians (OR 3.728, 95 % CI 2.858–4.863, p < 1.0 × 10−8; OR 4.334, 95 % CI 2.186–8.594, p = 2.6 × 10−6). However, there was no association between the Tallele and CTD-ILD in all subjects (OR 1.130, 95 % CI 0.937–1.363, p = 0.200), and in Europeans and Asians. Subgroup analysis by CTD type revealed no association between the Tallele and systemic sclerosis-associated ILD (SSc-ILD) and other CTD-ILDs.Conclusions: The MUC5B rs35705950 T/G polymorphism confers susceptibility to IPF in Europeans and Asians, but is not associated with susceptibility to CTD-ILD.

AB - Objective: To explore whether the mucin (MUC) 5B rs35705950 T/G polymorphism confers susceptibility to idiopathic pulmonary fibrosis (IPF).Methods: A meta-analysis was conducted to determine associations between the MUC5B rs35705950 T/G polymorphism and either IPF or connective tissue disease-associated interstitial lung disease (CTD-ILD). We used the allele contrast, recessive, dominant, and additive models. A total of 12 IPF studies comprising 2859 patients and 6901 controls and four CTD-ILD studies involving 903 patients and 3306 controls were included in the meta-analysis.Results: There was a significant association between the Tallele of the MUC5B rs35705950 polymorphism and IPF in all subjects (OR 3.768, 95 % CI 2.935–4.836, p < 1.0 × 10−8). Analysis after stratification by ethnicity indicated that the Tallele was significantly associated with IPF in Europeans and Asians (OR 3.728, 95 % CI 2.858–4.863, p < 1.0 × 10−8; OR 4.334, 95 % CI 2.186–8.594, p = 2.6 × 10−6). However, there was no association between the Tallele and CTD-ILD in all subjects (OR 1.130, 95 % CI 0.937–1.363, p = 0.200), and in Europeans and Asians. Subgroup analysis by CTD type revealed no association between the Tallele and systemic sclerosis-associated ILD (SSc-ILD) and other CTD-ILDs.Conclusions: The MUC5B rs35705950 T/G polymorphism confers susceptibility to IPF in Europeans and Asians, but is not associated with susceptibility to CTD-ILD.

KW - IPF

KW - Meta-analysis

KW - MUC5B

KW - Polymorphism

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