@article{ce9d60766f2344fdaabd107030d9b214,
title = "A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2",
abstract = "Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10-14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10-7). Of the adiponectinassociated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10-165), ADIPOQ (P = 1.8 × 10-22), PEPD (P = 3.6 × 10-12), CMIP (P = 2.1 × 10-10), ZNF664 (P = 2.3 × 10-7) and GPR109A (P = 7.4 × 10-6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10-7). We further confirmed the independence of two pairs of closely located loci (<2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P = 3.3 × 10-4), high density lipoprotein cholesterol (HDL-C, P = 4.9 × 10-4) and body mass index (BMI)-adjusted waist-hip ratio (P = 9.8 × 10-3). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms.",
author = "Ying Wu and He Gao and Huaixing Li and Yasuharu Tabara and Masahiro Nakatochi and Chiu, {Yen Feng} and Park, {Eun Jung} and Wanqing Wen and Adair, {Linda S.} and Borja, {Judith B.} and Qiuyin Cai and Chang, {Yi Cheng} and Peng Chen and Croteau-Chonka, {Damien C.} and Fogarty, {Marie P.} and Wei Gan and He, {Chih Tsueng} and Hsiung, {Chao A.} and Hwu, {Chii Min} and Sahoko Ichihara and Michiya Igase and Jaeseong Jo and Norihiro Kato and Ryuichi Kawamoto and Kuzawa, {Christophor W.} and Lee, {Jeannette J.M.} and Jianjun Liu and Ling Lu and Mcdade, {Thomas W.} and Haruhiko Osawa and Sheu, {Wayne H.H.} and Yvonne Teo and Swarooparani Vadlamudi and {Van Dam}, {Rob M.} and Yiqin Wang and Xiang, {Yong Bing} and Ken Yamamoto and Xingwang Ye and Young, {Terri L.} and Wei Zheng and Jingwen Zhu and Shu, {Xiao Ou} and Chol Shin and Jee, {Sun Ha} and Chuang, {Lee Ming} and Tetsuro Miki and Mitsuhiro Yokota and Xu Lin and Mohlke, {Karen L.} and Tai, {E. Shyong}",
note = "Funding Information: The Singapore Prospective Study Programme (SP2) was supported by the Biomedical Research Council (grant number 03/ 1/27/18/216) and the National Medical Research Council (grant numbers 0838/2004 and NMRC/CSI/0002/2005). The Korean Cancer Prevention Study II (KCPS-II) was supported by an extramural grant from the Seoul R&BD program, Republic of Korea (10526); a grant from the National R&D Program for Cancer Control; Ministry for Health, Welfare and Family Affairs, Republic of Korea (0920330); the National Research Foundation of Korea (NRF) grant, funded by the Korea government (MEST) (No.2011-0029348); and a grant from the National R&D Program for Cancer Control; Ministry for Health, Welfare and Family Affairs, Republic of Korea (1220180). The Cebu Longitudinal Health and Nutrition Survey (CLHNS) was supported by National Institutes of Health grants DK078150, TW005596, and HL085144 and pilot funds from RR020649, ES010126, and DK056350. The Nutrition and Health of Aging Population in China (NHAPC) was supported by research grants including the National High Technology Research and Development Program (2009AA022704), Knowledge Innovation Program (KSCX2-EW-R-10), the National Natural Science Foundation of China (30930081, 81021002, 81170734), and the National Key Basic Research Program of China (2012CB524900). The Ansan Cohort (Ansan) was supported by a fund (2007-E71001-00, 2008-E71001-00) by research of Korea Centers for Disease Control and Prevention and partially supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A000385). The Kita-Nagoya Genomic Epidemiology study (KING) was supported in part by Grants-in-Aid for Scientific Research including those of Categories (A) and (B) from the Japan Society for the Promotion of Science (17209021 and 21390209) and of Priority Area {\textquoteleft}Applied Genomics{\textquoteright} (1601223, 17019028, 18018020, and 20018026) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) was supported by Grants (NSC94-3112-B-002-019, NSC95-3112-B-002-002 and NSC96-3112-B-002-002) from the National Science Council of Taiwan. The SAPPHIRe follow-up studies were supported by National Health Research Institutes (NHRI) in Taiwan through the following grants: EC0950806, N06213, 200701083R, 95-11-20A, BS-092( 097)-PP-01, PH-98( 102)-PP03 and PH-98( 102)-PP04. The Anti-aging Center Study (AAC) and the Nomura Study (Nomura) were supported by a Grant-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology of Japan; a Science and Technology Incubation Program in Advanced Regions from the Japan Science and Technology Agency; a Grant-in-Aid for Scientific Research from the Japan Arteriosclerosis Prevention Fund; and a Research Promotion Award of Ehime University. The Shanghai Men{\textquoteright}s Health Study (SMHS) was supported by a grant from the National Institutes of Health (R01 CA082729).",
year = "2014",
month = feb,
doi = "10.1093/hmg/ddt488",
language = "English",
volume = "23",
pages = "1108--1119",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "4",
}
