TY - JOUR
T1 - A meta-analysis of the association between CTLA-4 +49 A/G, -318 C/T, and IL-1 polymorphisms and susceptibility to cervical cancer
AU - Lee, Y. H.
AU - Song, G. G.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.
AB - Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.
KW - Cervical cancer
KW - Cytotoxic T lymphocyte antigen-4
KW - Interleukin-l
KW - Meta-analysis
KW - Polymorphism
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U2 - 10.4149/neo_2014_060
DO - 10.4149/neo_2014_060
M3 - Article
C2 - 24712845
AN - SCOPUS:84904399708
VL - 61
SP - 481
EP - 490
JO - Neoplasma
JF - Neoplasma
SN - 0028-2685
IS - 4
ER -