A meta-analysis of the association between CTLA-4 +49 A/G, -318 C/T, and IL-1 polymorphisms and susceptibility to cervical cancer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.

Original languageEnglish
Pages (from-to)481-490
Number of pages10
JournalNeoplasma
Volume61
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

CTLA-4 Antigen
Interleukin-1
Uterine Cervical Neoplasms
Meta-Analysis
Interleukin-1 Receptors
Alleles
Genotype

Keywords

  • Cervical cancer
  • Cytotoxic T lymphocyte antigen-4
  • Interleukin-l
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research

Cite this

@article{b1c1744477284f1b84cdad62d010ad80,
title = "A meta-analysis of the association between CTLA-4 +49 A/G, -318 C/T, and IL-1 polymorphisms and susceptibility to cervical cancer",
abstract = "Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95{\%} CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95{\%} CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95{\%} CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95{\%} CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95{\%} CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95{\%} CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.",
keywords = "Cervical cancer, Cytotoxic T lymphocyte antigen-4, Interleukin-l, Meta-analysis, Polymorphism",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2014",
month = "1",
day = "1",
doi = "10.4149/neo_2014_060",
language = "English",
volume = "61",
pages = "481--490",
journal = "Neoplasma",
issn = "0028-2685",
publisher = "Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences",
number = "4",

}

TY - JOUR

T1 - A meta-analysis of the association between CTLA-4 +49 A/G, -318 C/T, and IL-1 polymorphisms and susceptibility to cervical cancer

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.

AB - Our aim was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and interleukin-1 (IL-1) polymorphisms are associated with cervical cancer. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, IL-1B -511 C/T, and IL-1 receptor antagonist (IL-1RN) polymorphisms and cervical cancer. We included 15 studies on cervical cancer. The meta-analysis showed a significant association between cervical cancer and the CTLA-4 +49 G allele when all studies were considered (OR = 0.822, 95% CI 0.731-0.924, p = 0.001). Stratification by ethnicity indicated an association between the CTLA-4 +49 GG+GA genotype and cervical cancer in East Asians (OR = 0.708, 95% CI 0.532-0.943, p = 0.018). However, no association was found between cervical cancer and the CTLA-4 -318 C/T polymorphism. Meta-analysis showed an association between cervical cancer and the IL-1B -511 T allele (OR = 1.380, 95% CI 1.048-1.816, p = 0.022), and stratification by ethnicity indicated an association between the IL-1B -511 CC+CT genotype in East Asians (OR = 1.622, 95% CI 1.227-2.43, p = 0.001). An association was found between the IL-1RN*2 allele and cervical cancer in Indians, but not in Europeans (OR = 2.154, 95% CI 1.547-2.948, p = 1.6 × 10-7; OR = 1.269, 95% CI 0.969-1.661, p = 0.083). The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.

KW - Cervical cancer

KW - Cytotoxic T lymphocyte antigen-4

KW - Interleukin-l

KW - Meta-analysis

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84904399708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904399708&partnerID=8YFLogxK

U2 - 10.4149/neo_2014_060

DO - 10.4149/neo_2014_060

M3 - Article

C2 - 24712845

AN - SCOPUS:84904399708

VL - 61

SP - 481

EP - 490

JO - Neoplasma

JF - Neoplasma

SN - 0028-2685

IS - 4

ER -