Abstract
Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility. Methods: Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. Results: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR = 1.102, 95% CI = 0.830-1.462, p = 0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR = 0.958, 95% CI = 0.811-1.132, p = 0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR = 1.234, 95% CI = 0.908-1.677, p = 0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS. Conclusions: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans.
| Original language | English |
|---|---|
| Pages (from-to) | 299-311 |
| Number of pages | 13 |
| Journal | Immunological Investigations |
| Volume | 43 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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Keywords
- CCR5-Δ32 polymorphism
- Meta-analysis
- Multiple sclerosis
ASJC Scopus subject areas
- Immunology
Cite this
A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility. / Song, Gwan Gyu; Lee, Young Ho.
In: Immunological Investigations, Vol. 43, No. 4, 01.01.2014, p. 299-311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility
AU - Song, Gwan Gyu
AU - Lee, Young Ho
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility. Methods: Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. Results: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR = 1.102, 95% CI = 0.830-1.462, p = 0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR = 0.958, 95% CI = 0.811-1.132, p = 0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR = 1.234, 95% CI = 0.908-1.677, p = 0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS. Conclusions: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans.
AB - Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility. Methods: Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. Results: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR = 1.102, 95% CI = 0.830-1.462, p = 0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR = 0.958, 95% CI = 0.811-1.132, p = 0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR = 1.234, 95% CI = 0.908-1.677, p = 0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS. Conclusions: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans.
KW - CCR5-Δ32 polymorphism
KW - Meta-analysis
KW - Multiple sclerosis
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U2 - 10.3109/08820139.2013.845204
DO - 10.3109/08820139.2013.845204
M3 - Article
C2 - 24295368
AN - SCOPUS:84897978799
VL - 43
SP - 299
EP - 311
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 4
ER -