Abstract
Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 517-518 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
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Keywords
- Basement membrane
- Glomerular endothelium
- Microfluidics
- Podocytes
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
A microfluidic 3D in vitro model of glomerular endothelium. / Kim, J.; Han, S.; Nam, J.; Chung, Seok; Lee, E. Y.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. p. 517-518.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - A microfluidic 3D in vitro model of glomerular endothelium
AU - Kim, J.
AU - Han, S.
AU - Nam, J.
AU - Chung, Seok
AU - Lee, E. Y.
PY - 2016
Y1 - 2016
N2 - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.
AB - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.
KW - Basement membrane
KW - Glomerular endothelium
KW - Microfluidics
KW - Podocytes
UR - http://www.scopus.com/inward/record.url?scp=85014295836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014295836&partnerID=8YFLogxK
M3 - Conference contribution
SP - 517
EP - 518
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
ER -