A microfluidic 3D in vitro model of glomerular endothelium

J. Kim, S. Han, J. Nam, Seok Chung, E. Y. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages517-518
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 2016 Oct 92016 Oct 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period16/10/916/10/13

Keywords

  • Basement membrane
  • Glomerular endothelium
  • Microfluidics
  • Podocytes

ASJC Scopus subject areas

  • Control and Systems Engineering

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