TY - GEN
T1 - A microfluidic 3D in vitro model of glomerular endothelium
AU - Kim, J.
AU - Han, S.
AU - Nam, J.
AU - Chung, S.
AU - Lee, E. Y.
N1 - Funding Information:
This research was supported by National Research Foundation of Korea (2014M3A7B4052193). This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2015R1D1A1A02060785).
PY - 2016
Y1 - 2016
N2 - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.
AB - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.
KW - Basement membrane
KW - Glomerular endothelium
KW - Microfluidics
KW - Podocytes
UR - http://www.scopus.com/inward/record.url?scp=85014295836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014295836&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85014295836
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 517
EP - 518
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -