A microfluidic 3D in vitro model of glomerular endothelium

J. Kim; S. Han; J. Nam; Seok Chung; E. Y. Lee

A microfluidic 3D in vitro model of glomerular endothelium

J. Kim, S. Han, J. Nam, Seok Chung, E. Y. Lee

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Publisher	Chemical and Biological Microsystems Society
Pages	517-518
Number of pages	2
ISBN (Electronic)	9780979806490
Publication status	Published - 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13

Other

Other	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country	Ireland
City	Dublin
Period	16/10/9 → 16/10/13

Keywords

Basement membrane
Glomerular endothelium
Microfluidics
Podocytes

ASJC Scopus subject areas

Control and Systems Engineering

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Kim, J, Han, S, Nam, J, Chung, S & Lee, EY 2016, A microfluidic 3D in vitro model of glomerular endothelium. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 517-518, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 16/10/9.

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author = "J. Kim and S. Han and J. Nam and Seok Chung and Lee, {E. Y.}",

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AU - Kim, J.

AU - Han, S.

AU - Nam, J.

AU - Chung, Seok

AU - Lee, E. Y.

PY - 2016

Y1 - 2016

N2 - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.

AB - Glommerular filtration barrier (GFB) provides almost total reaction of large protein. The filtration function of GFB is come from its unique structure composed of podocytes, glomerular basement membrane and glomerular endothelium. Here, we developed microfluidic 3D in vitro model for glomerular endothelium. The model can incorporate co culture of podocytes and synthetic basement membrane. Permeability of the glomerular endothelium was significantly enhanced by synthetic basement membrane and podocytes. It suggests our model can be promising tool to investigate GFB function under precisely reconstituted 3D integrated microenvironments.

KW - Basement membrane

KW - Glomerular endothelium

KW - Microfluidics

KW - Podocytes

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BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

PB - Chemical and Biological Microsystems Society

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Y2 - 9 October 2016 through 13 October 2016

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