A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins

Yoon Jung Choi, Sukyung Chae, Jeong Hun Kim, Joong Yull Park, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we introduce a microfluidic system to analyze the effect of oligomeric assemblies of amyloid beta on neurons quantitatively with well-organized in vivo-like microenvironment. By generating extremely slow flow rate and gradient of oligomeric assemblies of amyloid beta, our microfluidic platform simulates the regulated intramembrane proteolysis (RIP), a convergence physiological mechanism.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages902-904
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Fingerprint

Amyloid beta-Peptides
Amyloid
Microfluidics
Proteolysis
Proteins
Neurons
Flow rate

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Choi, Y. J., Chae, S., Kim, J. H., Park, J. Y., & Lee, S. H. (2012). A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 902-904). Chemical and Biological Microsystems Society.

A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins. / Choi, Yoon Jung; Chae, Sukyung; Kim, Jeong Hun; Park, Joong Yull; Lee, Sang Hoon.

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 902-904.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Choi, YJ, Chae, S, Kim, JH, Park, JY & Lee, SH 2012, A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, pp. 902-904, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, Japan, 12/10/28.
Choi YJ, Chae S, Kim JH, Park JY, Lee SH. A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 902-904
Choi, Yoon Jung ; Chae, Sukyung ; Kim, Jeong Hun ; Park, Joong Yull ; Lee, Sang Hoon. / A microfluidic culture system for analysis of neurotoxicity of oligomeric assemblies of amyloid beta proteins. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 902-904
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