TY - JOUR
T1 - A Minireview on Inertial Microfluidics Fundamentals
T2 - Inertial Particle Focusing and Secondary Flow
AU - Chung, Aram J.
N1 - Funding Information:
Acknowledgements A.J.C. thanks Prof. Ian Papautsky at University of Illinois at Chicago and Dr. Kevin Paulsen at Rensselaer Polytechnic Institute (presently at Lawrence Livermore National Laboratory) for their useful comments. A.J.C. acknowledges funding from Korea University Grant, and National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07045538).
Publisher Copyright:
© 2019, The Korean BioChip Society and Springer.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - In 1961, Segre and Silberberg first reported the tubular pinch effect and numerous theoretical studies were subsequently published to explain the inertial particle migration phenomenon. Presently, as fluid mechanics meets micro- and nanotechnology, theoretical studies on intrinsic particle migration and flow phenomena associated with inertia are being experimentally tested and validated. This collective study on the fluid-particle-structure phenomena in microchannels involving fluid inertia is called, “inertial microfluidics”. Beyond theoretical studies, now inertial microfluidics has been gaining much attention from various research fields ranging from biomedicine to industry. Despite the positive contributions, there is still a lack of clear understanding of intrinsic inertial effects in microchannels. Therefore, this minireview introduces the mechanisms and underlying physics in inertial microfluidic systems with specific focuses on inertial particle migration and secondary flow, and outlines the opportunities provided by inertial microfluidics, along with an outlook on the field.
AB - In 1961, Segre and Silberberg first reported the tubular pinch effect and numerous theoretical studies were subsequently published to explain the inertial particle migration phenomenon. Presently, as fluid mechanics meets micro- and nanotechnology, theoretical studies on intrinsic particle migration and flow phenomena associated with inertia are being experimentally tested and validated. This collective study on the fluid-particle-structure phenomena in microchannels involving fluid inertia is called, “inertial microfluidics”. Beyond theoretical studies, now inertial microfluidics has been gaining much attention from various research fields ranging from biomedicine to industry. Despite the positive contributions, there is still a lack of clear understanding of intrinsic inertial effects in microchannels. Therefore, this minireview introduces the mechanisms and underlying physics in inertial microfluidic systems with specific focuses on inertial particle migration and secondary flow, and outlines the opportunities provided by inertial microfluidics, along with an outlook on the field.
KW - Fluid inertia
KW - Inertial microfluidic physics
KW - Inertial microfluidics
KW - Inertial particle migration
KW - Secondary flow
UR - http://www.scopus.com/inward/record.url?scp=85063261262&partnerID=8YFLogxK
U2 - 10.1007/s13206-019-3110-1
DO - 10.1007/s13206-019-3110-1
M3 - Review article
AN - SCOPUS:85063261262
SN - 1976-0280
VL - 13
SP - 53
EP - 63
JO - Biochip Journal
JF - Biochip Journal
IS - 1
ER -