A mouse model for peripheral neuropathy produced by a partial injury of the nerve supplying the tail

Seung Keun Back, Backil Sung, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We attempted to develop a mouse model for peripheral neuropathy by a partial injury of the nerve supplying the tail. Under enflurane anesthesia, the unilateral superior caudal trunk was resected between the S3 and S4 spinal nerves. Tests for thermal allodynia were conducted by immersing the tail into 4 or 38°C water. The mechanical allodynia was assessed by stimulating the tail with a von Frey hair (1.96 mN, 0.2 g). After the nerve injury, the experimental animals had shorter tail withdrawal latencies to cold and warm water immersion than the presurgical latency, and exhibited an increase in tail response to von Frey stimulation. We interpret these abnormal sensitivities as the signs of mechanical, cold and warm allodynia following the superior caudal trunk injury in the mouse.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalNeuroscience Letters
Volume322
Issue number3
DOIs
Publication statusPublished - 2002 Apr 12

Keywords

  • Allodynia
  • Animal model
  • Hyperalgesia
  • Mouse
  • Neuropathic pain
  • Peripheral nerve injury

ASJC Scopus subject areas

  • Neuroscience(all)

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