A multi-center prospective randomized controlled trial (phase III) comparing the quality of life between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy for gastric Cancer (study protocol)

Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae Seok Min, Ye Seob Jee, Oh Jeong, Hyundong Chae, Sung Il Choi, Hua Huang, Sungsoo Park

Research output: Contribution to journalArticle

Abstract

Background: KLASS (the Korean Laparoendoscopic Gastrointestinal Surgery Study) is a time-honored study group that has established laparoscopic surgery for gastrointestinal disease in Korea and has performed some important studies for the rationale of laparoscopic gastrointestinal surgery. A multi-center RCT (randomized controlled trial) to compare the quality of life (QOL) of patients undergoing totally laparoscopic distal gastrectomy (TLDG) and laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer, named as KLASS 07, has been currently prepared in Korea. Methods: Patients diagnosed as gastric cancer, with clinical stage IA (T1N0M0) or IB (T1N1M0 / T2N0M0) according to the 7th edition of the Americal Joint Committee on Cancer System, were randomized to receive either TLDG or LADG. For surgical quality control, the surgeons participating in this trial had to have performed at least 50 gastrectomies and at least 30 gastrectomies annually (regardless of open or laparoscopic surgery for gastric cancer). The patients who are allocated to TLDG group undergo intracorporeal anastomosis and those who are assigned to LADG undergo extracorporeal anastomosis for gastrointestinal reconstruction. Discussion: Thirty-one surgeons from 26 institutions were engaged in this trial. The primary endpoint is 30-day morbidity, and secondary endpoint is QOL assessed by the questionnaire score. The KLASS 07 trial is the first multi-center RCT to investigate whether there are significant and quantifiable differences between the QOL of TLDG and LADG. The findings from this trial are expected to be the critical clues for designing the detailed procedures during laparoscopic surgery for gastric cancer. Trial registration: The protocol of KLASS 07 (CKLASS 01) was registered in http://register.clinicaltrials.gov as NCT03393182 (Date of registration: January 2nd, 2018.).

Original languageEnglish
Article number206
JournalBMC Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - 2019 Mar 7

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Gastrectomy
Laparoscopy
Stomach Neoplasms
Randomized Controlled Trials
Quality of Life
Korea
Gastrointestinal Diseases
Quality Control
Morbidity

Keywords

  • Gastric cancer
  • Laparoscopy-assisted distal gastrectomy
  • Randomized controlled trial
  • Totally laparoscopic distal gastrectomy

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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A multi-center prospective randomized controlled trial (phase III) comparing the quality of life between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy for gastric Cancer (study protocol). / Lee, Chang Min; Park, Ji Ho; In Choi, Chang; Lee, Han Hong; Min, Jae Seok; Jee, Ye Seob; Jeong, Oh; Chae, Hyundong; Choi, Sung Il; Huang, Hua; Park, Sungsoo.

In: BMC Cancer, Vol. 19, No. 1, 206, 07.03.2019.

Research output: Contribution to journalArticle

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AU - Lee, Han Hong

AU - Min, Jae Seok

AU - Jee, Ye Seob

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