A multicenter, eight-week treatment, single-step titration, open-label study assessing the percentage of korean dyslipidemic patients achieving LDL cholesterol target with atorvastatin starting doses of 10 mg, 20 mg and 40 mg

Cheol Whan Lee, Sang Hong Baek, Taek Jong Hong, Young Jin Choi, Young Jo Kim, Tae Hoon Ahn, Sang Hyun Ihm, Jang Ho Bae, Soon Jun Hong, Doo Il Kim, Young Keun Ahn, Seung Ho Hur, Dae Gyun Park, Dong Ju Choi, Seung Uk Lee, Bum Soo Kim, Kyu Hyung Ryu, Yang Soo Jang, Sang Hoon Lee, Ki Bae SeungHyo Soo Kim

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Abstract

Background: This study was designed to evaluate the safety and efficacy of algorithm-based atorvastatin therapy initiated at different starting doses of 10, 20, and 40 mg in Korean dyslipidemic patients. Methods: Five hundred seventy-four patients were screened, and 425 were enrolled (low risk, n=29; intermediate risk, n=45; high risk, n=351). The starting dose depended on a patient's cardiovascular risk and LDL-cholesterol (LDL-C) levels. Results: Of the patients, 253 (59.5%), 63 (14.8%) and 109 (25.6%) patients were assigned at baseline to 10 mg, 20 mg and 40 mg atorvastatin, respectively. 390 patients (91.8%) completed the study, and 35 discontinued prematurely. No patient in the low or intermediate risk groups was titrated to 80 mg at Week 4, whereas, 26 in the high risk group were. 81.9% of patients achieved their LDL-C target at Week 4, which was sustained through to Week 8 (86.0%). 89.1% of patients who were not titrated achieved their LDL-C target at Week 8, and 82.1% of patients who were titrated 1 step up achieved their LDL-C target at Week 8. Overall, about 40% reduction in LDL-C, non-HDL-C levels, and LDL-C/HDL-C ratio was observed during the follow-up. Triglyceride was reduced by ∼10% by Week 8. HDL cholesterol was slightly increased over 8 weeks (2.6%). Atorvastatin was well tolerated at all dose levels. Conclusions: Patient-tailored statin therapy according to an individual's risk category and LDL-C levels was safe and effective with a quick achievement of LDL-C target in Korean dyslipidemic patients.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalCardiovascular Drugs and Therapy
Volume24
Issue number2
DOIs
Publication statusPublished - 2010 Apr 1

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Keywords

  • Atorvastatin
  • Dyslipidemia
  • Flexible-starting dose
  • Target goal achievement

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Lee, C. W., Baek, S. H., Hong, T. J., Choi, Y. J., Kim, Y. J., Ahn, T. H., Ihm, S. H., Bae, J. H., Hong, S. J., Kim, D. I., Ahn, Y. K., Hur, S. H., Park, D. G., Choi, D. J., Lee, S. U., Kim, B. S., Ryu, K. H., Jang, Y. S., Lee, S. H., ... Kim, H. S. (2010). A multicenter, eight-week treatment, single-step titration, open-label study assessing the percentage of korean dyslipidemic patients achieving LDL cholesterol target with atorvastatin starting doses of 10 mg, 20 mg and 40 mg. Cardiovascular Drugs and Therapy, 24(2), 181-188. https://doi.org/10.1007/s10557-010-6225-0