A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy

Nam Hyuk Cho, Taek Chin Cheong, Ji Hyun Min, Jun Hua Wu, Sang Jin Lee, Daehong Kim, Jae Seong Yang, Sanguk Kim, Young-geun Kim, Seung Yong Seong

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

Dendritic cell-based cancer immunotherapy requires tumour antigens to be delivered efficiently into dendritic cells and their migration to be monitored in vivo. Nanoparticles have been explored as carriers for antigen delivery, but applications have been limited by the toxicity of the solvents used to make nanoparticles, and by the need to use transfection agents to deliver nanoparticles into cells. Here we show that an iron oxide-zinc oxide core-shell nanoparticle can deliver carcinoembryonic antigen into dendritic cells while simultaneously acting as an imaging agent. The nanoparticle-antigen complex is efficiently taken up by dendritic cells within one hour and can be detected in vitro by confocal microscopy and in vivo by magnetic resonance imaging. Mice immunized with dendritic cells containing the nanoparticle-antigen complex showed enhanced tumour antigen specific T-cell responses, delayed tumour growth and better survival than controls.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalNature Nanotechnology
Volume6
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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antigens
Antigens
Immunotherapy
Nanoparticles
Dendritic Cells
cancer
nanoparticles
cells
Tumors
Neoplasms
tumors
Neoplasm Antigens
Zinc Oxide
Imaging techniques
T-cells
Confocal microscopy
Carcinoembryonic Antigen
Magnetic resonance
Zinc oxide
Iron oxides

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Cho, N. H., Cheong, T. C., Min, J. H., Wu, J. H., Lee, S. J., Kim, D., ... Seong, S. Y. (2010). A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nature Nanotechnology, 6(10), 675-682. https://doi.org/10.1038/nnano.2011.149

A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. / Cho, Nam Hyuk; Cheong, Taek Chin; Min, Ji Hyun; Wu, Jun Hua; Lee, Sang Jin; Kim, Daehong; Yang, Jae Seong; Kim, Sanguk; Kim, Young-geun; Seong, Seung Yong.

In: Nature Nanotechnology, Vol. 6, No. 10, 01.10.2010, p. 675-682.

Research output: Contribution to journalArticle

Cho, NH, Cheong, TC, Min, JH, Wu, JH, Lee, SJ, Kim, D, Yang, JS, Kim, S, Kim, Y & Seong, SY 2010, 'A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy', Nature Nanotechnology, vol. 6, no. 10, pp. 675-682. https://doi.org/10.1038/nnano.2011.149
Cho, Nam Hyuk ; Cheong, Taek Chin ; Min, Ji Hyun ; Wu, Jun Hua ; Lee, Sang Jin ; Kim, Daehong ; Yang, Jae Seong ; Kim, Sanguk ; Kim, Young-geun ; Seong, Seung Yong. / A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. In: Nature Nanotechnology. 2010 ; Vol. 6, No. 10. pp. 675-682.
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