A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy

Nam Hyuk Cho, Taek Chin Cheong, Ji Hyun Min, Jun Hua Wu, Sang Jin Lee, Daehong Kim, Jae Seong Yang, Sanguk Kim, Young Keun Kim, Seung Yong Seong

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

Dendritic cell-based cancer immunotherapy requires tumour antigens to be delivered efficiently into dendritic cells and their migration to be monitored in vivo. Nanoparticles have been explored as carriers for antigen delivery, but applications have been limited by the toxicity of the solvents used to make nanoparticles, and by the need to use transfection agents to deliver nanoparticles into cells. Here we show that an iron oxide-zinc oxide core-shell nanoparticle can deliver carcinoembryonic antigen into dendritic cells while simultaneously acting as an imaging agent. The nanoparticle-antigen complex is efficiently taken up by dendritic cells within one hour and can be detected in vitro by confocal microscopy and in vivo by magnetic resonance imaging. Mice immunized with dendritic cells containing the nanoparticle-antigen complex showed enhanced tumour antigen specific T-cell responses, delayed tumour growth and better survival than controls.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalNature Nanotechnology
Volume6
Issue number10
DOIs
Publication statusPublished - 2010 Oct

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Cho, N. H., Cheong, T. C., Min, J. H., Wu, J. H., Lee, S. J., Kim, D., Yang, J. S., Kim, S., Kim, Y. K., & Seong, S. Y. (2010). A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nature Nanotechnology, 6(10), 675-682. https://doi.org/10.1038/nnano.2011.149