A nationwide seroepidemiology of hepatitis C virus infection in South Korea

Do Young Kim, In Hee Kim, Sook Hyang Jeong, Yong Kyun Cho, Joon Hyoek Lee, Young Joo Jin, Don Lee, Dong Jin Suh, Kwang Hyub Han, Neung Hwa Park, Ha Yan Kang, Young Kul Jung, Young Seok Kim, Kyung Ah Kim, Youn Jae Lee, Byung Seok Lee, Hyung Joon Yim, Heon Ju Lee, Soon Koo Baik, Won Young TakSun Jae Lee, Woo Jin Chung, Sung Kyu Choi, Eun Young Cho, Jeong Heo, Dong Joon Kim, Byung Cheol Song, Man Woo Kim, Jun Lee, Hee Bok Chae, Dae Hee Choi, Hwa Young Choi, Moran Ki

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background & Aims: The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods: From January to December 2009, a total of 291 314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results: Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 20-29 years to 2.31% in those >70 years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53-2.07%), mid-level in Seoul and surrounding districts (0.50-0.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV (-) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. Conclusion: The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.

Original languageEnglish
Pages (from-to)586-594
Number of pages9
JournalLiver International
Volume33
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

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Republic of Korea
Virus Diseases
Hepacivirus
RNA
Infection
Serum
Hepatitis C Antibodies
Seroepidemiologic Studies
Korea
Alanine Transaminase
Antiviral Agents
Genotype
Lipids
Health
Therapeutics
Population

Keywords

  • Hepatitis C virus
  • Infection
  • Korea
  • Prevalence

ASJC Scopus subject areas

  • Hepatology

Cite this

Kim, D. Y., Kim, I. H., Jeong, S. H., Cho, Y. K., Lee, J. H., Jin, Y. J., ... Ki, M. (2013). A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver International, 33(4), 586-594. https://doi.org/10.1111/liv.12108

A nationwide seroepidemiology of hepatitis C virus infection in South Korea. / Kim, Do Young; Kim, In Hee; Jeong, Sook Hyang; Cho, Yong Kyun; Lee, Joon Hyoek; Jin, Young Joo; Lee, Don; Suh, Dong Jin; Han, Kwang Hyub; Park, Neung Hwa; Kang, Ha Yan; Jung, Young Kul; Kim, Young Seok; Kim, Kyung Ah; Lee, Youn Jae; Lee, Byung Seok; Yim, Hyung Joon; Lee, Heon Ju; Baik, Soon Koo; Tak, Won Young; Lee, Sun Jae; Chung, Woo Jin; Choi, Sung Kyu; Cho, Eun Young; Heo, Jeong; Kim, Dong Joon; Song, Byung Cheol; Kim, Man Woo; Lee, Jun; Chae, Hee Bok; Choi, Dae Hee; Choi, Hwa Young; Ki, Moran.

In: Liver International, Vol. 33, No. 4, 01.04.2013, p. 586-594.

Research output: Contribution to journalArticle

Kim, DY, Kim, IH, Jeong, SH, Cho, YK, Lee, JH, Jin, YJ, Lee, D, Suh, DJ, Han, KH, Park, NH, Kang, HY, Jung, YK, Kim, YS, Kim, KA, Lee, YJ, Lee, BS, Yim, HJ, Lee, HJ, Baik, SK, Tak, WY, Lee, SJ, Chung, WJ, Choi, SK, Cho, EY, Heo, J, Kim, DJ, Song, BC, Kim, MW, Lee, J, Chae, HB, Choi, DH, Choi, HY & Ki, M 2013, 'A nationwide seroepidemiology of hepatitis C virus infection in South Korea', Liver International, vol. 33, no. 4, pp. 586-594. https://doi.org/10.1111/liv.12108
Kim DY, Kim IH, Jeong SH, Cho YK, Lee JH, Jin YJ et al. A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver International. 2013 Apr 1;33(4):586-594. https://doi.org/10.1111/liv.12108
Kim, Do Young ; Kim, In Hee ; Jeong, Sook Hyang ; Cho, Yong Kyun ; Lee, Joon Hyoek ; Jin, Young Joo ; Lee, Don ; Suh, Dong Jin ; Han, Kwang Hyub ; Park, Neung Hwa ; Kang, Ha Yan ; Jung, Young Kul ; Kim, Young Seok ; Kim, Kyung Ah ; Lee, Youn Jae ; Lee, Byung Seok ; Yim, Hyung Joon ; Lee, Heon Ju ; Baik, Soon Koo ; Tak, Won Young ; Lee, Sun Jae ; Chung, Woo Jin ; Choi, Sung Kyu ; Cho, Eun Young ; Heo, Jeong ; Kim, Dong Joon ; Song, Byung Cheol ; Kim, Man Woo ; Lee, Jun ; Chae, Hee Bok ; Choi, Dae Hee ; Choi, Hwa Young ; Ki, Moran. / A nationwide seroepidemiology of hepatitis C virus infection in South Korea. In: Liver International. 2013 ; Vol. 33, No. 4. pp. 586-594.
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abstract = "Background & Aims: The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods: From January to December 2009, a total of 291 314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results: Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78{\%}. Anti-HCV prevalence in female patients (0.83{\%}) was higher than that in male patients (0.75{\%}). Gradual increase in anti-HCV positivity was observed, from 0.34{\%} in those aged 20-29 years to 2.31{\%} in those >70 years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53-2.07{\%}), mid-level in Seoul and surrounding districts (0.50-0.61{\%}) and lower in Jeju (0.23{\%}). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV (-) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1{\%}) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84{\%} of patients. Conclusion: The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.",
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AU - Lee, Joon Hyoek

AU - Jin, Young Joo

AU - Lee, Don

AU - Suh, Dong Jin

AU - Han, Kwang Hyub

AU - Park, Neung Hwa

AU - Kang, Ha Yan

AU - Jung, Young Kul

AU - Kim, Young Seok

AU - Kim, Kyung Ah

AU - Lee, Youn Jae

AU - Lee, Byung Seok

AU - Yim, Hyung Joon

AU - Lee, Heon Ju

AU - Baik, Soon Koo

AU - Tak, Won Young

AU - Lee, Sun Jae

AU - Chung, Woo Jin

AU - Choi, Sung Kyu

AU - Cho, Eun Young

AU - Heo, Jeong

AU - Kim, Dong Joon

AU - Song, Byung Cheol

AU - Kim, Man Woo

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AB - Background & Aims: The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods: From January to December 2009, a total of 291 314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results: Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 20-29 years to 2.31% in those >70 years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53-2.07%), mid-level in Seoul and surrounding districts (0.50-0.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV (-) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. Conclusion: The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.

KW - Hepatitis C virus

KW - Infection

KW - Korea

KW - Prevalence

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