A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Seulki Lee, Eui Joon Cha, Kyeongsoon Park, Seung Young Lee, Jin Ki Hong, In Cheol Sun, Sang Yoon Kim, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim, Cheol Hee Ahn

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

Original languageEnglish
Pages (from-to)2804-2807
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number15
DOIs
Publication statusPublished - 2008 Mar 31
Externally publishedYes

Fingerprint

Bearings (structural)
Preclinical Drug Evaluations
Matrix Metalloproteinases
Gold
Nanoparticles
Tumors
Screening
Peptide Hydrolases
Dyes
Fluorescence
Infrared radiation
Imaging techniques
Pharmaceutical Preparations
Experiments
Coloring Agents
Metalloproteases
Neoplasms

Keywords

  • Cancer diagnosis
  • Drug screening
  • Fluorescent probes
  • Gold
  • Imaging agents

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination. / Lee, Seulki; Cha, Eui Joon; Park, Kyeongsoon; Lee, Seung Young; Hong, Jin Ki; Sun, In Cheol; Kim, Sang Yoon; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwang Meyung; Ahn, Cheol Hee.

In: Angewandte Chemie - International Edition, Vol. 47, No. 15, 31.03.2008, p. 2804-2807.

Research output: Contribution to journalArticle

Lee, Seulki ; Cha, Eui Joon ; Park, Kyeongsoon ; Lee, Seung Young ; Hong, Jin Ki ; Sun, In Cheol ; Kim, Sang Yoon ; Choi, Kuiwon ; Kwon, Ick Chan ; Kim, Kwang Meyung ; Ahn, Cheol Hee. / A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination. In: Angewandte Chemie - International Edition. 2008 ; Vol. 47, No. 15. pp. 2804-2807.
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AU - Sun, In Cheol

AU - Kim, Sang Yoon

AU - Choi, Kuiwon

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