A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer's disease

Sang Wook Yoo, Cheol E. Han, Joseph S. Shin, Sang Won Seo, Duk L. Na, Marcus Kaiser, Yong Jeong, Jun Kyung Seong

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Cognitive reserve is the ability to sustain cognitive function even with a certain amount of brain damages. Here we investigate the neural compensation mechanism of cognitive reserve from the perspective of structural brain connectivity. Our goal was to show that normal people with high education levels (i.e., cognitive reserve) maintain abundant pathways connecting any two brain regions, providing better compensation or resilience after brain damage. Accordingly, patients with high education levels show more deterioration in structural brain connectivity than those with low education levels before symptoms of Alzheimer's disease (AD) become apparent. To test this hypothesis, we use network flow measuring the number of alternative paths between two brain regions in the brain network. The experimental results show that for normal aging, education strengthens network reliability, as measured through flow values, in a subnetwork centered at the supramarginal gyrus. For AD, a subnetwork centered at the left middle frontal gyrus shows a negative correlation between flow and education, which implies more collapse in structural brain connectivity for highly educated patients. We conclude that cognitive reserve may come from the ability of network reorganization to secure the information flow within the brain network, therefore making it more resistant to disease progress.

Original languageEnglish
Article number10057
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 May 20

Fingerprint

Cognitive Reserve
Alzheimer Disease
Brain
Education
Aptitude
Parietal Lobe
Cognition

ASJC Scopus subject areas

  • General

Cite this

A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer's disease. / Wook Yoo, Sang; Han, Cheol E.; Shin, Joseph S.; Won Seo, Sang; Na, Duk L.; Kaiser, Marcus; Jeong, Yong; Seong, Jun Kyung.

In: Scientific Reports, Vol. 5, 10057, 20.05.2015.

Research output: Contribution to journalArticle

Wook Yoo, Sang ; Han, Cheol E. ; Shin, Joseph S. ; Won Seo, Sang ; Na, Duk L. ; Kaiser, Marcus ; Jeong, Yong ; Seong, Jun Kyung. / A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer's disease. In: Scientific Reports. 2015 ; Vol. 5.
@article{47b3841d15024ac59cb06f1344feb59e,
title = "A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer's disease",
abstract = "Cognitive reserve is the ability to sustain cognitive function even with a certain amount of brain damages. Here we investigate the neural compensation mechanism of cognitive reserve from the perspective of structural brain connectivity. Our goal was to show that normal people with high education levels (i.e., cognitive reserve) maintain abundant pathways connecting any two brain regions, providing better compensation or resilience after brain damage. Accordingly, patients with high education levels show more deterioration in structural brain connectivity than those with low education levels before symptoms of Alzheimer's disease (AD) become apparent. To test this hypothesis, we use network flow measuring the number of alternative paths between two brain regions in the brain network. The experimental results show that for normal aging, education strengthens network reliability, as measured through flow values, in a subnetwork centered at the supramarginal gyrus. For AD, a subnetwork centered at the left middle frontal gyrus shows a negative correlation between flow and education, which implies more collapse in structural brain connectivity for highly educated patients. We conclude that cognitive reserve may come from the ability of network reorganization to secure the information flow within the brain network, therefore making it more resistant to disease progress.",
author = "{Wook Yoo}, Sang and Han, {Cheol E.} and Shin, {Joseph S.} and {Won Seo}, Sang and Na, {Duk L.} and Marcus Kaiser and Yong Jeong and Seong, {Jun Kyung}",
year = "2015",
month = "5",
day = "20",
doi = "10.1038/srep10057",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - A network flow-based analysis of cognitive reserve in normal ageing and Alzheimer's disease

AU - Wook Yoo, Sang

AU - Han, Cheol E.

AU - Shin, Joseph S.

AU - Won Seo, Sang

AU - Na, Duk L.

AU - Kaiser, Marcus

AU - Jeong, Yong

AU - Seong, Jun Kyung

PY - 2015/5/20

Y1 - 2015/5/20

N2 - Cognitive reserve is the ability to sustain cognitive function even with a certain amount of brain damages. Here we investigate the neural compensation mechanism of cognitive reserve from the perspective of structural brain connectivity. Our goal was to show that normal people with high education levels (i.e., cognitive reserve) maintain abundant pathways connecting any two brain regions, providing better compensation or resilience after brain damage. Accordingly, patients with high education levels show more deterioration in structural brain connectivity than those with low education levels before symptoms of Alzheimer's disease (AD) become apparent. To test this hypothesis, we use network flow measuring the number of alternative paths between two brain regions in the brain network. The experimental results show that for normal aging, education strengthens network reliability, as measured through flow values, in a subnetwork centered at the supramarginal gyrus. For AD, a subnetwork centered at the left middle frontal gyrus shows a negative correlation between flow and education, which implies more collapse in structural brain connectivity for highly educated patients. We conclude that cognitive reserve may come from the ability of network reorganization to secure the information flow within the brain network, therefore making it more resistant to disease progress.

AB - Cognitive reserve is the ability to sustain cognitive function even with a certain amount of brain damages. Here we investigate the neural compensation mechanism of cognitive reserve from the perspective of structural brain connectivity. Our goal was to show that normal people with high education levels (i.e., cognitive reserve) maintain abundant pathways connecting any two brain regions, providing better compensation or resilience after brain damage. Accordingly, patients with high education levels show more deterioration in structural brain connectivity than those with low education levels before symptoms of Alzheimer's disease (AD) become apparent. To test this hypothesis, we use network flow measuring the number of alternative paths between two brain regions in the brain network. The experimental results show that for normal aging, education strengthens network reliability, as measured through flow values, in a subnetwork centered at the supramarginal gyrus. For AD, a subnetwork centered at the left middle frontal gyrus shows a negative correlation between flow and education, which implies more collapse in structural brain connectivity for highly educated patients. We conclude that cognitive reserve may come from the ability of network reorganization to secure the information flow within the brain network, therefore making it more resistant to disease progress.

UR - http://www.scopus.com/inward/record.url?scp=84930227319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930227319&partnerID=8YFLogxK

U2 - 10.1038/srep10057

DO - 10.1038/srep10057

M3 - Article

C2 - 25992968

AN - SCOPUS:84930227319

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10057

ER -