A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells

Haeun Kwon, Quynh Nhu Nguyen, Myung Woo Na, Ki Hyun Kim, Yuanqiang Guo, Joung Han Yim, Sang Hee Shim, Jae Jin Kim, Ki Sung Kang, Dongho Lee

Research output: Contribution to journalArticlepeer-review

Abstract

A new α-pyrone analog, arthrifuranone A (1) was isolated from an EtOAc-extract of Arthrinium pseudosinense culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using MS and NMR spectroscopic techniques, and the absolute configuration was established by the Mosher’s method and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4 + analysis. The isolated compound was evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells. Compound 1 showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 3.125 μM via phosphorylation of estrogen receptor-α.

Original languageEnglish
Pages (from-to)893-897
Number of pages5
JournalJournal of Antibiotics
Volume74
Issue number12
DOIs
Publication statusPublished - 2021 Dec

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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