A new function of glucocorticoid receptor: regulation of mRNA stability

Ok Hyun Park, Eunjin Do, Yoon Ki Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

It has long been thought that glucocorticoid receptor (GR) functions as a DNA-binding transcription factor in response to its ligand (a glucocorticoid) and thus regulates various cellular and physiological processes. It is also known that GR can bind not only to DNA but also to mRNA; this observation points to the possible role of GR in mRNA metabolism. Recent data revealed a molecular mechanism by which binding of GR to target mRNA elicits rapid mRNA degradation. GR binds to specific RNA sequences regardless of the presence of a ligand. In the presence of a ligand, however, the mRNA-associated GR can recruit PNRC2 and UPF1, both of which are specific factors involved in nonsense-mediated mRNA decay (NMD). PNRC2 then recruits the decapping complex, consequently promoting mRNA degradation. This mode of mRNA decay is termed "GR-mediated mRNA decay" (GMD). Further research demonstrated that GMD plays a critical role in chemotaxis of immune cells by targeting CCL2 mRNA. All these observations provide molecular insights into a previously unappreciated function of GR in posttranscriptional regulation of gene expression.

Original languageEnglish
Pages (from-to)367-368
Number of pages2
JournalBMB Reports
Volume48
Issue number7
DOIs
Publication statusPublished - 2015

Keywords

  • Chemotaxis
  • Glucocorticoid receptor
  • mRNA decay
  • PNRC2
  • UPF1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'A new function of glucocorticoid receptor: regulation of mRNA stability'. Together they form a unique fingerprint.

  • Cite this