A new risk score for ventricular tachyarrhythmia in acute myocardial infarction with preserved left ventricular ejection fraction

Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators

Research output: Contribution to journalArticle

Abstract

Background: Ventricular tachycardia or fibrillation (VT/VF) is a major cause of sudden cardiac death after acute myocardial infarction (AMI). This study aims to investigate the clinical characteristics and outcomes of VT/VF, to identify the variables associated with VT/VF, and to construct a new scoring system. Methods: Patients with relatively preserved left ventricular ejection fraction (LVEF) (≥40%) included in the Korea Acute Myocardial Infarction Registry-National Institutes of Health registry were enrolled in this study. Among 13,109 patients in the registry, a total of 10,334 (78.8%) had relatively preserved LVEF after AMI. Patients were divided into two groups based on whether they experienced life-threatening VT/VF during hospitalization or not. The predictors for VT/VF during hospitalization were assessed. In-hospital mortality and complications were recorded. Results: A total of 358 (3.5%) experienced life-threatening VT/VF. The VT/VF group was at an increased risk of in-hospital mortality (odds ratio 2.99) and cardiac death (odds ratio 3.40). Variables of diagnosis, Killip class, smoking, initial rhythm, left bundle branch block, and LVEF were significant indicators of VT/VF. A new risk score system yielded acceptable discrimination function (c-statistics = 0.773). Conclusions: Relatively preserved LVEF patients could still be at risk of life-threatening VT/VF, which is related to a poor prognosis during the admission period. This new scoring system can be adopted to stratify the risk of VT/VF.

Original languageEnglish
Pages (from-to)420-426
Number of pages7
JournalJournal of Cardiology
Volume72
Issue number5
DOIs
Publication statusPublished - 2018 Nov 1

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Tachycardia
Stroke Volume
Myocardial Infarction
Registries
Hospital Mortality
Hospitalization
Odds Ratio
Bundle-Branch Block
Sudden Cardiac Death
National Institutes of Health (U.S.)
Ventricular Fibrillation
Ventricular Tachycardia
Korea
Smoking

Keywords

  • Myocardial infarction
  • Prognosis
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A new risk score for ventricular tachyarrhythmia in acute myocardial infarction with preserved left ventricular ejection fraction. / Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators.

In: Journal of Cardiology, Vol. 72, No. 5, 01.11.2018, p. 420-426.

Research output: Contribution to journalArticle

Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators. / A new risk score for ventricular tachyarrhythmia in acute myocardial infarction with preserved left ventricular ejection fraction. In: Journal of Cardiology. 2018 ; Vol. 72, No. 5. pp. 420-426.
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abstract = "Background: Ventricular tachycardia or fibrillation (VT/VF) is a major cause of sudden cardiac death after acute myocardial infarction (AMI). This study aims to investigate the clinical characteristics and outcomes of VT/VF, to identify the variables associated with VT/VF, and to construct a new scoring system. Methods: Patients with relatively preserved left ventricular ejection fraction (LVEF) (≥40{\%}) included in the Korea Acute Myocardial Infarction Registry-National Institutes of Health registry were enrolled in this study. Among 13,109 patients in the registry, a total of 10,334 (78.8{\%}) had relatively preserved LVEF after AMI. Patients were divided into two groups based on whether they experienced life-threatening VT/VF during hospitalization or not. The predictors for VT/VF during hospitalization were assessed. In-hospital mortality and complications were recorded. Results: A total of 358 (3.5{\%}) experienced life-threatening VT/VF. The VT/VF group was at an increased risk of in-hospital mortality (odds ratio 2.99) and cardiac death (odds ratio 3.40). Variables of diagnosis, Killip class, smoking, initial rhythm, left bundle branch block, and LVEF were significant indicators of VT/VF. A new risk score system yielded acceptable discrimination function (c-statistics = 0.773). Conclusions: Relatively preserved LVEF patients could still be at risk of life-threatening VT/VF, which is related to a poor prognosis during the admission period. This new scoring system can be adopted to stratify the risk of VT/VF.",
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author = "{Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators} and Lee, {Seung Hun} and Jeong, {Myung Ho} and Kim, {Ju Han} and Kim, {Min Chul} and Sim, {Doo Sun} and Hong, {Young Joon} and Youngkeun Ahn and Chae, {Shung Chull} and Seong, {In Whan} and Park, {Jong Sun} and Chae, {Jei Keon} and Hur, {Seung Ho} and Cha, {Kwang Soo} and Kim, {Hyo Soo} and Gwon, {Hyeon Cheol} and Seung, {Ki Bae} and Seung-Woon Rha",
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T1 - A new risk score for ventricular tachyarrhythmia in acute myocardial infarction with preserved left ventricular ejection fraction

AU - Other Korea Acute Myocardial Infarction Registry (KAMIR) investigators

AU - Lee, Seung Hun

AU - Jeong, Myung Ho

AU - Kim, Ju Han

AU - Kim, Min Chul

AU - Sim, Doo Sun

AU - Hong, Young Joon

AU - Ahn, Youngkeun

AU - Chae, Shung Chull

AU - Seong, In Whan

AU - Park, Jong Sun

AU - Chae, Jei Keon

AU - Hur, Seung Ho

AU - Cha, Kwang Soo

AU - Kim, Hyo Soo

AU - Gwon, Hyeon Cheol

AU - Seung, Ki Bae

AU - Rha, Seung-Woon

PY - 2018/11/1

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N2 - Background: Ventricular tachycardia or fibrillation (VT/VF) is a major cause of sudden cardiac death after acute myocardial infarction (AMI). This study aims to investigate the clinical characteristics and outcomes of VT/VF, to identify the variables associated with VT/VF, and to construct a new scoring system. Methods: Patients with relatively preserved left ventricular ejection fraction (LVEF) (≥40%) included in the Korea Acute Myocardial Infarction Registry-National Institutes of Health registry were enrolled in this study. Among 13,109 patients in the registry, a total of 10,334 (78.8%) had relatively preserved LVEF after AMI. Patients were divided into two groups based on whether they experienced life-threatening VT/VF during hospitalization or not. The predictors for VT/VF during hospitalization were assessed. In-hospital mortality and complications were recorded. Results: A total of 358 (3.5%) experienced life-threatening VT/VF. The VT/VF group was at an increased risk of in-hospital mortality (odds ratio 2.99) and cardiac death (odds ratio 3.40). Variables of diagnosis, Killip class, smoking, initial rhythm, left bundle branch block, and LVEF were significant indicators of VT/VF. A new risk score system yielded acceptable discrimination function (c-statistics = 0.773). Conclusions: Relatively preserved LVEF patients could still be at risk of life-threatening VT/VF, which is related to a poor prognosis during the admission period. This new scoring system can be adopted to stratify the risk of VT/VF.

AB - Background: Ventricular tachycardia or fibrillation (VT/VF) is a major cause of sudden cardiac death after acute myocardial infarction (AMI). This study aims to investigate the clinical characteristics and outcomes of VT/VF, to identify the variables associated with VT/VF, and to construct a new scoring system. Methods: Patients with relatively preserved left ventricular ejection fraction (LVEF) (≥40%) included in the Korea Acute Myocardial Infarction Registry-National Institutes of Health registry were enrolled in this study. Among 13,109 patients in the registry, a total of 10,334 (78.8%) had relatively preserved LVEF after AMI. Patients were divided into two groups based on whether they experienced life-threatening VT/VF during hospitalization or not. The predictors for VT/VF during hospitalization were assessed. In-hospital mortality and complications were recorded. Results: A total of 358 (3.5%) experienced life-threatening VT/VF. The VT/VF group was at an increased risk of in-hospital mortality (odds ratio 2.99) and cardiac death (odds ratio 3.40). Variables of diagnosis, Killip class, smoking, initial rhythm, left bundle branch block, and LVEF were significant indicators of VT/VF. A new risk score system yielded acceptable discrimination function (c-statistics = 0.773). Conclusions: Relatively preserved LVEF patients could still be at risk of life-threatening VT/VF, which is related to a poor prognosis during the admission period. This new scoring system can be adopted to stratify the risk of VT/VF.

KW - Myocardial infarction

KW - Prognosis

KW - Ventricular fibrillation

KW - Ventricular tachycardia

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