A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Eun Young Bae, Hyuncheol Oh, Won Keun Oh, Min Soo Kim, Beom Seok Kim, Bo Yeon Kim, Cheon Bae Sohn, Hiroyuki Osada, Jong Seog Ahn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.

Original languageEnglish
Pages (from-to)869-870
Number of pages2
JournalPlanta Medica
Volume70
Issue number9
DOIs
Publication statusPublished - 2004 Sep 1
Externally publishedYes

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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    Bae, E. Y., Oh, H., Oh, W. K., Kim, M. S., Kim, B. S., Kim, B. Y., Sohn, C. B., Osada, H., & Ahn, J. S. (2004). A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme. Planta Medica, 70(9), 869-870. https://doi.org/10.1055/s-2004-827238