A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Zhigang Yang, Yanxia He, Jae Hong Lee, Weon Sik Chae, Wen Xiu Ren, Joung Hae Lee, Chulhun Kang, Jong Seung Kim

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57 Citations (Scopus)


We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1. This journal is

Original languageEnglish
Pages (from-to)11672-11675
Number of pages4
JournalChemical Communications
Issue number79
Publication statusPublished - 2014 Oct 11


ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

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