A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Zhigang Yang; Yanxia He; Jae Hong Lee; Weon Sik Chae; Wen Xiu Ren; Joung Hae Lee; Chulhun Kang; Jong Seung Kim

doi:10.1039/c4cc04915b

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Zhigang Yang, Yanxia He, Jae Hong Lee, Weon Sik Chae, Wen Xiu Ren, Joung Hae Lee, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

Original language	English
Pages (from-to)	11672-11675
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	79
DOIs	https://doi.org/10.1039/c4cc04915b
Publication status	Published - 2014 Sep 9

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc04915b

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A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum. / Yang, Zhigang; He, Yanxia; Lee, Jae Hong; Chae, Weon Sik; Ren, Wen Xiu; Lee, Joung Hae; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 50, No. 79, 09.09.2014, p. 11672-11675.

Research output: Contribution to journal › Article › peer-review

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title = "A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum",

abstract = "We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.",

author = "Zhigang Yang and Yanxia He and Lee, {Jae Hong} and Chae, {Weon Sik} and Ren, {Wen Xiu} and Lee, {Joung Hae} and Chulhun Kang and Kim, {Jong Seung}",

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AU - Yang, Zhigang

AU - He, Yanxia

AU - Lee, Jae Hong

AU - Chae, Weon Sik

AU - Ren, Wen Xiu

AU - Lee, Joung Hae

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2014/9/9

Y1 - 2014/9/9

N2 - We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

AB - We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

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ER -

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Abstract

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