Abstract
We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1. This journal is
| Original language | English |
|---|---|
| Pages (from-to) | 11672-11675 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 79 |
| DOIs | |
| Publication status | Published - 2014 Oct 11 |
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Ceramics and Composites
- Electronic, Optical and Magnetic Materials
- Surfaces, Coatings and Films
- Materials Chemistry
- Metals and Alloys
- Medicine(all)
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Yang, Z., He, Y., Lee, J. H., Chae, W. S., Ren, W. X., Lee, J. H., Kang, C., & Kim, J. S. (2014). A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum. Chemical Communications, 50(79), 11672-11675. https://doi.org/10.1039/c4cc04915b