A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Zhigang Yang, Yanxia He, Jae Hong Lee, Weon Sik Chae, Wen Xiu Ren, Joung Hae Lee, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1. This journal is

Original languageEnglish
Pages (from-to)11672-11675
Number of pages4
JournalChemical Communications
Volume50
Issue number79
DOIs
Publication statusPublished - 2014 Oct 11

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Viscosity
Endoplasmic Reticulum
Tunicamycin
Fluorescent Dyes
Permittivity
Fluorescence
nile red
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum. / Yang, Zhigang; He, Yanxia; Lee, Jae Hong; Chae, Weon Sik; Ren, Wen Xiu; Lee, Joung Hae; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 50, No. 79, 11.10.2014, p. 11672-11675.

Research output: Contribution to journalArticle

Yang, Zhigang ; He, Yanxia ; Lee, Jae Hong ; Chae, Weon Sik ; Ren, Wen Xiu ; Lee, Joung Hae ; Kang, Chulhun ; Kim, Jong Seung. / A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum. In: Chemical Communications. 2014 ; Vol. 50, No. 79. pp. 11672-11675.
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