A noble RBC aggregometer with vibration-induced disaggregation mechanism

Sehyun Shin, J. H. Jang, M. S. Park, Y. H. Ku, J. S. Suh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aggregation of red blood cells (RBCs) is a major determinant of blood flow resistance passing through various veins. Available techniques for measuring RBC aggregation often require pretreating and washing after each measurement, which is not optimal for day-to-day clinical use. A laser reflection technique has been combined with a vibration-aided disaggregation mechanism, which shows significant advances in aggregometer design, operation and data analysis. The essential features of this design are in its simplicity and a disposable element that is in contact with the blood sample. Using extremely small quantities of blood, the RBCs subjected to vibrations can be quickly and completely disaggregated. This is followed by measuring the backscattered light intensity. The measurements with the present sensor were compared with those of a commercial aggregometer and a strong correlation was found between them. The newly-developed optical aggregometer can measure the RBC aggregability difference between young and old cell suspension with ease and accuracy.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalKorea Australia Rheology Journal
Volume17
Issue number1
Publication statusPublished - 2005 Mar 1
Externally publishedYes

Fingerprint

erythrocytes
Blood
vibration
blood
flow resistance
design analysis
washing
blood flow
veins
determinants
luminous intensity
Agglomeration
sensors
Washing
cells
Suspensions
lasers
Cells
Lasers
Sensors

Keywords

  • Aggregation
  • Light
  • Red blood cell
  • Reflection
  • Vibration

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

Cite this

Shin, S., Jang, J. H., Park, M. S., Ku, Y. H., & Suh, J. S. (2005). A noble RBC aggregometer with vibration-induced disaggregation mechanism. Korea Australia Rheology Journal, 17(1), 9-13.

A noble RBC aggregometer with vibration-induced disaggregation mechanism. / Shin, Sehyun; Jang, J. H.; Park, M. S.; Ku, Y. H.; Suh, J. S.

In: Korea Australia Rheology Journal, Vol. 17, No. 1, 01.03.2005, p. 9-13.

Research output: Contribution to journalArticle

Shin, S, Jang, JH, Park, MS, Ku, YH & Suh, JS 2005, 'A noble RBC aggregometer with vibration-induced disaggregation mechanism', Korea Australia Rheology Journal, vol. 17, no. 1, pp. 9-13.
Shin, Sehyun ; Jang, J. H. ; Park, M. S. ; Ku, Y. H. ; Suh, J. S. / A noble RBC aggregometer with vibration-induced disaggregation mechanism. In: Korea Australia Rheology Journal. 2005 ; Vol. 17, No. 1. pp. 9-13.
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