A novel artificial renal microchip employing polymeric nanofibers membrane

Kwang Ho Lee, Jae Gwan Kim, Duck Joong Kim, Sang Hoon Lee, Byoung Goo Min

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

In this study, a novel artificial renal replacement system is presented using a biocompatible polymeric nanofibers and MEMS technology. Usually, a classical artificial renal replacement system employs a semi-permeable membrane based hemodialyzer that replaces an ability of the kidney by removing metabolic toxins through diffusion and hydraulic pressure gradients. But, it has some limits in efficient filtration of metabolic byproducts (e.g.: urea, creatinine, and so on). We have developed PDMS based artificial renal microchips (AR chip) integrating biocompatible polymeric nanofibers which are utilized for the filtration of blood. Here, we demonstrate a novel artificial renal chip by integrating a high efficient biocompatible polymeric nanofibers membrane with the PDMS based micro-fluidic platform. Via the optimization of PDMS micro fluidic channel network and the multiple packaging of nanofibers membrane, we will realize the portable and wearable artificial kidney system.

Original languageEnglish
Pages1094-1096
Number of pages3
Publication statusPublished - 2006
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 2006 Nov 52006 Nov 9

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period06/11/506/11/9

Keywords

  • Artificial kidney
  • Artificial renal microchip (AR chip)
  • Electrospinning
  • Nanofiber

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Lee, K. H., Kim, J. G., Kim, D. J., Lee, S. H., & Min, B. G. (2006). A novel artificial renal microchip employing polymeric nanofibers membrane. 1094-1096. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.