A novel artificial renal microchip employing polymeric nanofibers membrane

Kwang Ho Lee, Jae Gwan Kim, Duck Joong Kim, Sang Hoon Lee, Byoung Goo Min

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study, a novel artificial renal replacement system is presented using a biocompatible polymeric nanofibers and MEMS technology. Usually, a classical artificial renal replacement system employs a semi-permeable membrane based hemodialyzer that replaces an ability of the kidney by removing metabolic toxins through diffusion and hydraulic pressure gradients. But, it has some limits in efficient filtration of metabolic byproducts (e.g.: urea, creatinine, and so on). We have developed PDMS based artificial renal microchips (AR chip) integrating biocompatible polymeric nanofibers which are utilized for the filtration of blood. Here, we demonstrate a novel artificial renal chip by integrating a high efficient biocompatible polymeric nanofibers membrane with the PDMS based micro-fluidic platform. Via the optimization of PDMS micro fluidic channel network and the multiple packaging of nanofibers membrane, we will realize the portable and wearable artificial kidney system.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherJapan Academic Association Inc
Pages1094-1096
Number of pages3
Publication statusPublished - 2006 Jan 1
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 2006 Nov 52006 Nov 9

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period06/11/506/11/9

    Fingerprint

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lee, K. H., Kim, J. G., Kim, D. J., Lee, S. H., & Min, B. G. (2006). A novel artificial renal microchip employing polymeric nanofibers membrane. In Micro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1094-1096). Japan Academic Association Inc.