A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata

Dongho Lee, Muriel Cuendet, Jose Schunke Vigo, James G. Graham, Fernando Cabieses, Harry H S Fong, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

(Matrix presented) Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods. Compound 1 is based on an unprecedented stilbenolignan skeleton in which a stilbene moiety is linked with a phenylpropane unit through a dioxane bridge. Compounds 1 and 2 exhibited significant inhibitory activities against cyclooxygenases-1 and -2.

Original languageEnglish
Pages (from-to)2169-2170
Number of pages2
JournalOrganic Letters
Volume3
Issue number14
DOIs
Publication statusPublished - 2001 Jul 12
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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    Lee, D., Cuendet, M., Schunke Vigo, J., Graham, J. G., Cabieses, F., Fong, H. H. S., Pezzuto, J. M., & Kinghorn, A. D. (2001). A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. Organic Letters, 3(14), 2169-2170. https://doi.org/10.1021/ol015985j