A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata

Dongho Lee, Muriel Cuendet, Jose Schunke Vigo, James G. Graham, Fernando Cabieses, Harry H.S. Fong, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

(Matrix presented) Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods. Compound 1 is based on an unprecedented stilbenolignan skeleton in which a stilbene moiety is linked with a phenylpropane unit through a dioxane bridge. Compounds 1 and 2 exhibited significant inhibitory activities against cyclooxygenases-1 and -2.

Original languageEnglish
Pages (from-to)2169-2170
Number of pages2
JournalOrganic Letters
Volume3
Issue number14
DOIs
Publication statusPublished - 2001 Jul 12
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Lee, D., Cuendet, M., Schunke Vigo, J., Graham, J. G., Cabieses, F., Fong, H. H. S., Pezzuto, J. M., & Kinghorn, A. D. (2001). A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. Organic Letters, 3(14), 2169-2170. https://doi.org/10.1021/ol015985j