A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata

Dongho Lee, Muriel Cuendet, Jose Schunke Vigo, James G. Graham, Fernando Cabieses, Harry H S Fong, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

(Matrix presented) Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes aculeata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods. Compound 1 is based on an unprecedented stilbenolignan skeleton in which a stilbene moiety is linked with a phenylpropane unit through a dioxane bridge. Compounds 1 and 2 exhibited significant inhibitory activities against cyclooxygenases-1 and -2.

Original languageEnglish
Pages (from-to)2169-2170
Number of pages2
JournalOrganic Letters
Volume3
Issue number14
DOIs
Publication statusPublished - 2001 Jul 12
Externally publishedYes

Fingerprint

Arecaceae
Luteolin
Stilbenes
Cyclooxygenase 1
bioassay
stilbene
Bioassay
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Fractionation
musculoskeletal system
Skeleton
fractionation
Biological Assay
Seed
seeds
Seeds
matrices
isorhapontigenin
aiphanol

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Lee, D., Cuendet, M., Schunke Vigo, J., Graham, J. G., Cabieses, F., Fong, H. H. S., ... Kinghorn, A. D. (2001). A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. Organic Letters, 3(14), 2169-2170. https://doi.org/10.1021/ol015985j

A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. / Lee, Dongho; Cuendet, Muriel; Schunke Vigo, Jose; Graham, James G.; Cabieses, Fernando; Fong, Harry H S; Pezzuto, John M.; Kinghorn, A. Douglas.

In: Organic Letters, Vol. 3, No. 14, 12.07.2001, p. 2169-2170.

Research output: Contribution to journalArticle

Lee, D, Cuendet, M, Schunke Vigo, J, Graham, JG, Cabieses, F, Fong, HHS, Pezzuto, JM & Kinghorn, AD 2001, 'A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata', Organic Letters, vol. 3, no. 14, pp. 2169-2170. https://doi.org/10.1021/ol015985j
Lee D, Cuendet M, Schunke Vigo J, Graham JG, Cabieses F, Fong HHS et al. A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. Organic Letters. 2001 Jul 12;3(14):2169-2170. https://doi.org/10.1021/ol015985j
Lee, Dongho ; Cuendet, Muriel ; Schunke Vigo, Jose ; Graham, James G. ; Cabieses, Fernando ; Fong, Harry H S ; Pezzuto, John M. ; Kinghorn, A. Douglas. / A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata. In: Organic Letters. 2001 ; Vol. 3, No. 14. pp. 2169-2170.
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