A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid

Kyochan Kim, Eun Jung Kim, Byung Gon Ryu, Soojung Park, Yoon E. Choi, Ji Won Yang

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

The biology of Aurantiochytrium sp. KRS101 was thoroughly investigated to enhance its production of biodiesel and docosahexaenoic acid (DHA). Nutrients and salinity were optimized to prevent biomass loss due to cell rupture. Calculation of yield coefficients showed that nitrogen was mostly responsible for the early stage of cell growth or division, whereas carbon was necessary for the entire process of cell development, particularly cell enlargement during late stages. Using these distinctive yield coefficients, a modified fed-batch cultivation method was designed, resulting in increases in palmitic acid (PA) and DHA production of up to 137% and 29%, respectively. This modified fed-batch cultivation method, using appropriate supplies of nitrogen and carbon, may improve the yields of PA and DHA, thus expanding the biotechnological applications of Aurantiochytrium sp. KRS101.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalBioresource technology
Volume135
DOIs
Publication statusPublished - 2013 May
Externally publishedYes

Keywords

  • Aurantiochytrium sp.
  • Biodiesel
  • Docosahexaenoic acid
  • Modified fed-batch
  • Yield coefficients

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

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