A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-

Bryony A. Dickinson, Jihoon Jo, Heon Seok, Gi Hoon Son, Daniel J. Whitcomb, Ceri H. Davies, Morgan Sheng, Graham L. Collingridge, Kwangwook Cho

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background. Long-term depression (LTD) in the hippocampus can be induced by activation of different types of G-protein coupled receptors, in particular metabotropic glutamate receptors (mGluRs) and muscarinic acethycholine receptors (mAChRs). Since mGluRs and mAChRs activate the same G-proteins and isoforms of phospholipase C (PLC), it would be expected that these two forms of LTD utilise the same molecular mechanisms. However, we find a distinct mechanism of LTD involving GRIP and liprin-. Results. Whilst both forms of LTD require activation of tyrosine phosphatases and involve internalisation of AMPARs, they use different molecular interactions. Specifically, mAChR-LTD, but not mGluR-LTD, is blocked by peptides that inhibit the binding of GRIP to the AMPA receptor subunit GluA2 and the binding of GRIP to liprin-. Thus, different receptors that utilise the same G-proteins can regulate AMPAR trafficking and synaptic efficacy via distinct molecular mechanisms. Conclusion. Our results suggest that mAChR-LTD selectively involves interactions between GRIP and liprin-. These data indicate a novel mechanism of synaptic plasticity in which activation of M1 receptors results in AMPAR endocytosis, via a mechanism involving interactions between GluA2, GRIP and liprin-.

Original languageEnglish
Article number18
JournalMolecular Brain
Volume2
Issue number1
DOIs
Publication statusPublished - 2009 Aug 10
Externally publishedYes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

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    Dickinson, B. A., Jo, J., Seok, H., Son, G. H., Whitcomb, D. J., Davies, C. H., Sheng, M., Collingridge, G. L., & Cho, K. (2009). A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-. Molecular Brain, 2(1), [18]. https://doi.org/10.1186/1756-6606-2-18