A novel method for convenient assessment of arthritic pain in voluntarily walking rats

Sun Seek Min, Jeong Seok Han, Yang In Kim, Heung Sik Na, Young Wook Yoon, Seung Kil Hong, Hee Chul Han

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Quantification of arthritic pain can be very useful in elucidating the mechanisms of arthritis and in assessing the effect of anti-arthritic medication or treatment. Here we report a novel method that allows convenient measurements of the severity of arthritic pain in voluntarily walking rats. We constructed a device to measure the weight load on each leg while the animal was walking through a path, the bottom of which was equipped with strain gauge weight sensors. Using this device, we measured the weight load on the right hind leg before and after induction of arthritis by carrageenan injection into the knee joint cavity of this leg. The carrageenan injection resulted in a significant reduction of weight load on the affected leg; the load decreased to the minimum level at 4 h after the injection and gradually returned to the pre-injection level by the fifth day. Intraperitoneal administration of morphine at 5.5 h after carrageenan injection could reverse the weight load change. These results suggest that our new device is an effective tool for convenient measurements of arthritic pain in dynamic conditions like walking.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalNeuroscience Letters
Volume308
Issue number2
DOIs
Publication statusPublished - 2001 Aug 3

Keywords

  • Arthritis
  • Carrageenan
  • Inflammation
  • Pain
  • Weight bearing

ASJC Scopus subject areas

  • Neuroscience(all)

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