A novel polymer microneedle fabrication process for active fluidic delivery

Bernardo Cordovez, Aram Chung, Michael Mak, David Erickson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this article, we explore a new fabrication process for a flexible, all polymer, active fluidic delivery system, incorporating a fusion of laser micromachining and microfabrication techniques as well as rapid prototyping technology. Here, we show selective fluidic delivery from isolated microchannels through an electrochemically driven pumping reaction, demonstrate the dispensing of dose volumes up to 5.5 μl, and evaluate the device's performance in terms of its delivery speed and ejection efficiency. Finally, we move this work toward an implantable microfluidic drug delivery device by investigating the device's biocompatibility through a statistical approach that overviews the viability of bovine aortic endothelial cells on polyimide and silicon substrates.

Original languageEnglish
Pages (from-to)785-791
Number of pages7
JournalMicrofluidics and Nanofluidics
Volume10
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1
Externally publishedYes

Fingerprint

fluidics
Fluidics
delivery
Polymers
Fabrication
fabrication
Microfabrication
Endothelial cells
Micromachining
polymers
Rapid prototyping
Silicon
Microchannels
Drug delivery
Biocompatibility
Microfluidics
Polyimides
Fusion reactions
rapid prototyping
laser machining

Keywords

  • Electrochemistry
  • Implantable drug delivery
  • Microfluidics Polyimide
  • Rapid prototyping

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

Cite this

A novel polymer microneedle fabrication process for active fluidic delivery. / Cordovez, Bernardo; Chung, Aram; Mak, Michael; Erickson, David.

In: Microfluidics and Nanofluidics, Vol. 10, No. 4, 01.04.2011, p. 785-791.

Research output: Contribution to journalArticle

Cordovez, Bernardo ; Chung, Aram ; Mak, Michael ; Erickson, David. / A novel polymer microneedle fabrication process for active fluidic delivery. In: Microfluidics and Nanofluidics. 2011 ; Vol. 10, No. 4. pp. 785-791.
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