A novel t(8;13)(q21;q22) translocation in a pediatric lipoma

Jinglan Jin, Junqi Niu, Young Mi Kim, Xianfu Wang, David Parham, Robert Letton, Shibo Li, Ji Yun Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pediatric lipomas are rare and their etiology is unknown. As in adult lipomas, a segment of 12q13-q15 has been documented as a common chromosomal rearrangement region. Here, we report a pediatric lipoma case without rearrangement of 12q13-q15 but with an apparently balanced translocation involving chromosomes 8 and 13 [t(8;13)(q21;q22)] detected by routine cytogenetic analysis, and small deletions on 5q21.1 and 8q21.11 detected by array comparative genetic hybridization. The small deletion on 8q21.11 is possibly due to chromosomal instability at the breakpoint of the translocation.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalCancer Genetics
Volume204
Issue number11
DOIs
Publication statusPublished - 2011 Nov

Keywords

  • Array CGH
  • Chromosomal translocation
  • FISH
  • Lipoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Jin, J., Niu, J., Kim, Y. M., Wang, X., Parham, D., Letton, R., Li, S., & Lee, J. Y. (2011). A novel t(8;13)(q21;q22) translocation in a pediatric lipoma. Cancer Genetics, 204(11), 629-633. https://doi.org/10.1016/j.cancergen.2011.10.010