A novel tissue-engineered trachea with a mechanical behavior similar to native trachea

Jeong Hun Park, Jung Min Hong, Young Min Ju, Jin Woo Jung, Hyun Wook Kang, Sang Jin Lee, James J. Yoo, Sung Won Kim, Soo Hyun Kim, Dong Woo Cho

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A novel tissue-engineered trachea was developed with appropriate mechanical behavior and substantial regeneration of tracheal cartilage. We designed hollow bellows scaffold as a framework of a tissue-engineered trachea and demonstrated a reliable method for three-dimensional (3D) printing of monolithic bellows scaffold. We also functionalized gelatin sponge to allow sustained release of TGF-β1 for stimulating tracheal cartilage regeneration and confirmed that functionalized gelatin sponge induces cartilaginous tissue formation in vitro. A tissue-engineered trachea was then created by assembling chondrocytes-seeded functionalized gelatin sponges into the grooves of bellows scaffold and it showed very similar mechanical behavior to that of native trachea along with substantial regeneration of tracheal cartilage in vivo. The tissue-engineered trachea developed here represents a novel concept of tracheal substitute with appropriate mechanical behavior similar to native trachea for use in reconstruction of tracheal stenosis.

Original languageEnglish
Pages (from-to)106-115
Number of pages10
JournalBiomaterials
Volume62
DOIs
Publication statusPublished - 2015 Sep 1
Externally publishedYes

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Keywords

  • Appropriate mechanical behavior
  • Bellows scaffold
  • Heparinization
  • Indirect 3D printing
  • Tracheal cartilage regeneration

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Park, J. H., Hong, J. M., Ju, Y. M., Jung, J. W., Kang, H. W., Lee, S. J., Yoo, J. J., Kim, S. W., Kim, S. H., & Cho, D. W. (2015). A novel tissue-engineered trachea with a mechanical behavior similar to native trachea. Biomaterials, 62, 106-115. https://doi.org/10.1016/j.biomaterials.2015.05.008