A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

Hyung Joo Suh, J. H. Whang, H. Lee

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A peptide (F4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F4), at 30 mg kg-1 body weight of rat, antagonized the rat's pressor response to angiotensin I.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalBiotechnology Letters
Volume21
Issue number12
DOIs
Publication statusPublished - 1999 Dec 1

Keywords

  • Angiotensin converting enzyme
  • Corn gluten
  • Peptide inhibitor
  • Pescalase
  • Protease

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

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