A pilot study of F-18 FP-cit pet imaging in early-onset patients with parkinson’s disease

Parkin versus non-parkin mutation

Kyum Yil Kwon, Seong Beom Koh

Research output: Contribution to journalArticle

Abstract

Striatal dopaminergic dysfunction in early-onset Parkinson’s disease (PD) remains to be further elucidated. Thus, as a preliminary study, we aimed to investigate detailed patterns of dopaminergic depletion in five early-onset PD patients with dynamic N-(3-[(18) F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) scans. Two patients with parkin mutation showed more symmetric decrease of dopamine transporter (DAT) density in the putamen, whereas others displayed asymmetric reduction of DAT density in the putamen. Notably, only those with parkin mutation revealed more severe dopaminergic deficits in the anteroventral putamen rather than the posterodoral putamen. Our observation suggests, among PD patients, patients with parkin mutation may exhibit the different pattern of striatal dopaminergic depletion.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalNeuroQuantology
Volume16
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Parkinson disease
Putamen
Pets
mutations
Parkinson Disease
Corpus Striatum
transporter
dopamine
Dopamine Plasma Membrane Transport Proteins
Mutation
Nortropanes
depletion
Positron-Emission Tomography
positrons
tomography
Observation

Keywords

  • Dopamine depletion
  • Early-onset
  • Parkin mutation
  • Parkinson’s disease

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Developmental Neuroscience
  • Cognitive Neuroscience

Cite this

A pilot study of F-18 FP-cit pet imaging in early-onset patients with parkinson’s disease : Parkin versus non-parkin mutation. / Kwon, Kyum Yil; Koh, Seong Beom.

In: NeuroQuantology, Vol. 16, No. 1, 01.01.2018, p. 52-56.

Research output: Contribution to journalArticle

@article{85cc647ca2a9430f8d4b99e87a359397,
title = "A pilot study of F-18 FP-cit pet imaging in early-onset patients with parkinson’s disease: Parkin versus non-parkin mutation",
abstract = "Striatal dopaminergic dysfunction in early-onset Parkinson’s disease (PD) remains to be further elucidated. Thus, as a preliminary study, we aimed to investigate detailed patterns of dopaminergic depletion in five early-onset PD patients with dynamic N-(3-[(18) F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) scans. Two patients with parkin mutation showed more symmetric decrease of dopamine transporter (DAT) density in the putamen, whereas others displayed asymmetric reduction of DAT density in the putamen. Notably, only those with parkin mutation revealed more severe dopaminergic deficits in the anteroventral putamen rather than the posterodoral putamen. Our observation suggests, among PD patients, patients with parkin mutation may exhibit the different pattern of striatal dopaminergic depletion.",
keywords = "Dopamine depletion, Early-onset, Parkin mutation, Parkinson’s disease",
author = "Kwon, {Kyum Yil} and Koh, {Seong Beom}",
year = "2018",
month = "1",
day = "1",
doi = "10.14704/nq.2018.16.1.1148",
language = "English",
volume = "16",
pages = "52--56",
journal = "NeuroQuantology",
issn = "1303-5150",
publisher = "NeuroQuantology",
number = "1",

}

TY - JOUR

T1 - A pilot study of F-18 FP-cit pet imaging in early-onset patients with parkinson’s disease

T2 - Parkin versus non-parkin mutation

AU - Kwon, Kyum Yil

AU - Koh, Seong Beom

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Striatal dopaminergic dysfunction in early-onset Parkinson’s disease (PD) remains to be further elucidated. Thus, as a preliminary study, we aimed to investigate detailed patterns of dopaminergic depletion in five early-onset PD patients with dynamic N-(3-[(18) F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) scans. Two patients with parkin mutation showed more symmetric decrease of dopamine transporter (DAT) density in the putamen, whereas others displayed asymmetric reduction of DAT density in the putamen. Notably, only those with parkin mutation revealed more severe dopaminergic deficits in the anteroventral putamen rather than the posterodoral putamen. Our observation suggests, among PD patients, patients with parkin mutation may exhibit the different pattern of striatal dopaminergic depletion.

AB - Striatal dopaminergic dysfunction in early-onset Parkinson’s disease (PD) remains to be further elucidated. Thus, as a preliminary study, we aimed to investigate detailed patterns of dopaminergic depletion in five early-onset PD patients with dynamic N-(3-[(18) F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) scans. Two patients with parkin mutation showed more symmetric decrease of dopamine transporter (DAT) density in the putamen, whereas others displayed asymmetric reduction of DAT density in the putamen. Notably, only those with parkin mutation revealed more severe dopaminergic deficits in the anteroventral putamen rather than the posterodoral putamen. Our observation suggests, among PD patients, patients with parkin mutation may exhibit the different pattern of striatal dopaminergic depletion.

KW - Dopamine depletion

KW - Early-onset

KW - Parkin mutation

KW - Parkinson’s disease

UR - http://www.scopus.com/inward/record.url?scp=85041408474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041408474&partnerID=8YFLogxK

U2 - 10.14704/nq.2018.16.1.1148

DO - 10.14704/nq.2018.16.1.1148

M3 - Article

VL - 16

SP - 52

EP - 56

JO - NeuroQuantology

JF - NeuroQuantology

SN - 1303-5150

IS - 1

ER -